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Materials
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Design and Synthesis of Novel Optical Probes
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Design and Synthesis of Novel Optical Probes

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (15 November 2019) | Viewed by 19959

Special Issue Editors

Prof. Dr. Malgorzata Szczerska

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Guest Editor
Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Gdańsk, Poland
Interests: biophotonics; biomedical optics; fiber-optic sensors; optical sensors; low coherent interferometry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dror Fixler

E-Mail Website
Guest Editor
Faculty of Engineering; Head of the Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 5290002, Israel
Interests: fluorescence lifetime and anisotropy decay; fluorescence lifetime imaging; biological imaging based on fluorescence parameters; light–tissue interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to submit a manuscript for the Special Issue of Materials focused on the Design and Synthesis of Novel Optical Probes.

The use of optical probes for different kind of applications is currently undergoing a revolution, with the incorporation of many new kinds of optical techniques and new materials. Novel optical probes allow the visualization of different materials such as tissues, cells, proteins and macromolecular structures at all levels of resolution, functional states, chemical composition and dynamic analysis, by using photonic studies of nanoscale interactions in all disciplines (like biology and medicine), as well as sensing.

The last two decades have witnessed the explosion of nanoscale materials in optical probes for imaging and sensing. Recent integrative research efforts have included nanotechnology (fabrication and application) as a tool for developing new techniques and improving existing optical imaging techniques for real-time, sub-wavelength imaging of cellular processes; developing the next generation of nano-sensors to improve sensing applications; using nanoparticles or nanostructures for optical engineering methodologies; and very large scale and/or very sensitive detection down to the single molecule level.

The proposed Special Issue will focus on, but is not limited to, the following key items in optical, fluorescence, electron or X-ray microscopy with sensing applications: nanoparticle use in imaging and sensing; nanostructures used for sub-wavelength imaging; nanospectroscopy and nano-scale sensing applications. Papers will emphasize the fundamentals of photonics and sensing including:

  • development of novel optical probes for imaging or sensing,
  • functionalization of materials dedicated for novel optical probes,
  • optical imaging and sensing using nanophotonic optical probes ,
  • applications of nanophotonics (functionalized nanoparticles, surfaces, etc..)

Prof. Małgorzata Jędrzejewska-Szczerska
Prof. Dror Fixler
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • design of optical probes
  • development of optical probes for imaging
  • development of optical probes for sensing
  • development of new nanophotonics particles for optical sensing and imaging
  • development of new nanophotonics materials for optical sensing and imaging
  • functionalization of materials dedicated for novel optical probes
  • applications of nanophotonics

Published Papers (6 papers)

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Research

13 pages, 38145 KiB  
Article
Surface-Enhanced Absorption Spectroscopy for Optical Fiber Sensing
by Silje S. Fuglerud, Karolina Milenko, Astrid Aksnes and Dag R. Hjelme
Materials 2020, 13(1), 34; https://doi.org/10.3390/ma13010034 - 19 Dec 2019
Cited by 5 | Viewed by 2677
Abstract
Visible and near-infrared spectroscopy are widely used for sensing applications but suffer from poor signal-to-noise ratios for the detection of compounds with low concentrations. Enhancement by surface plasmon resonance is a popular technique that can be utilized to increase the signal of absorption [...] Read more.
Visible and near-infrared spectroscopy are widely used for sensing applications but suffer from poor signal-to-noise ratios for the detection of compounds with low concentrations. Enhancement by surface plasmon resonance is a popular technique that can be utilized to increase the signal of absorption spectroscopy due to the increased near-field created close to the plasmons. Despite interest in surface-enhanced infrared absorption spectroscopy (SEIRAS), the method is usually applied in lab setups rather than real-life sensing situations. This study aimed to achieve enhanced absorption from plasmons on a fiber-optic probe and thus move closer to applications of SEIRAS. A tapered coreless fiber coated with a 100 nm Au film supported signal enhancement at visible wavelengths. An increase in absorption was shown for two dyes spanning concentrations from 5 × 10−8 mol/L to 8 × 10−4 mol/L: Rhodamine 6G and Crystal Violet. In the presence of the Au film, the absorbance signal was 2–3 times higher than from an identically tapered uncoated fiber. The results confirm that the concept of SEIRAS can be implemented on an optical fiber probe, enabling enhanced signal detection in remote sensing applications. Full article
(This article belongs to the Special Issue Design and Synthesis of Novel Optical Probes)
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16 pages, 5976 KiB  
Article
Microwave-Assisted Synthesis and Characterization of Poly(L-lysine)-Based Polymer/Carbon Quantum Dot Nanomaterials for Biomedical Purposes
by Łukasz Janus, Marek Piątkowski and Julia Radwan-Pragłowska
Materials 2019, 12(23), 3825; https://doi.org/10.3390/ma12233825 - 21 Nov 2019
Cited by 11 | Viewed by 2641
Abstract
Carbon nanomaterials in the form of quantum dots have a high potential due to their luminescent properties and low cytotoxicity which allows their use in optical probes for use in bioimaging and biodetection. In this article, we present a novel type of nanomaterials [...] Read more.
Carbon nanomaterials in the form of quantum dots have a high potential due to their luminescent properties and low cytotoxicity which allows their use in optical probes for use in bioimaging and biodetection. In this article, we present a novel type of nanomaterials and their obtainment method under microwave-assisted conditions using poly(L-lysine) as a raw material. The ready products were characterized over their chemical structure, pH-dependent fluorescence properties and cytotoxicity on human dermal fibroblasts. Moreover, their antioxidant activity as well as ability to biologically active molecules (vitamins) and heavy metal ions detection was evaluated. The results confirmed the obtainment of biocompatible nanomaterials with advanced properties and good water solubility according to sustained development principles. Full article
(This article belongs to the Special Issue Design and Synthesis of Novel Optical Probes)
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10 pages, 1484 KiB  
Article
Optical Magnetometry Based on Nanodiamonds with Nitrogen-Vacancy Color Centers
by Adam M. Wojciechowski, Paulina Nakonieczna, Mariusz Mrózek, Krystian Sycz, Andrzej Kruk, Mateusz Ficek, Maciej Głowacki, Robert Bogdanowicz and Wojciech Gawlik
Materials 2019, 12(18), 2951; https://doi.org/10.3390/ma12182951 - 11 Sep 2019
Cited by 22 | Viewed by 4798
Abstract
Nitrogen-vacancy color centers in diamond are a very promising medium for many sensing applications such as magnetometry and thermometry. In this work, we study nanodiamonds deposited from a suspension onto glass substrates. Fluorescence and optically detected magnetic resonance spectra recorded with the dried-out [...] Read more.
Nitrogen-vacancy color centers in diamond are a very promising medium for many sensing applications such as magnetometry and thermometry. In this work, we study nanodiamonds deposited from a suspension onto glass substrates. Fluorescence and optically detected magnetic resonance spectra recorded with the dried-out nanodiamond ensembles are presented and a suitable scheme for tracking the magnetic-field value using a continuous poly-crystalline spectrum is introduced. Lastly, we demonstrate a remote-sensing capability of the high-numerical-aperture imaging fiber bundle with nanodiamonds deposited on its end facet. Full article
(This article belongs to the Special Issue Design and Synthesis of Novel Optical Probes)
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13 pages, 3412 KiB  
Article
Genetic Algorithm-Based Design for Metal-Enhanced Fluorescent Nanostructures
by Dror Fixler, Chen Tzur and Zeev Zalevsky
Materials 2019, 12(11), 1766; https://doi.org/10.3390/ma12111766 - 31 May 2019
Cited by 2 | Viewed by 2143
Abstract
In this paper, we present our optimization tool for fluorophore-conjugated metal nanostructures for the purpose of designing novel contrast agents for multimodal bioimaging. Contrast agents are of great importance to biological imaging. They usually include nanoelements causing a reduction in the need for [...] Read more.
In this paper, we present our optimization tool for fluorophore-conjugated metal nanostructures for the purpose of designing novel contrast agents for multimodal bioimaging. Contrast agents are of great importance to biological imaging. They usually include nanoelements causing a reduction in the need for harmful materials and improvement in the quality of the captured images. Thus, smart design tools that are based on evolutionary algorithms and machine learning definitely provide a technological leap in the fluorescence bioimaging world. This article proposes the usage of properly designed metallic structures that change their fluorescence properties when the dye molecules and the plasmonic nanoparticles interact. The nanostructures design and evaluation processes are based upon genetic algorithms, and they result in an optimal separation distance, orientation angles, and aspect ratio of the metal nanostructure. Full article
(This article belongs to the Special Issue Design and Synthesis of Novel Optical Probes)
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16 pages, 5871 KiB  
Article
Microstructured Optical Waveguide-Based Endoscopic Probe Coated with Silica Submicron Particles
by Timur Ermatov, Yury V. Petrov, Sergei V. German, Anastasia A. Zanishevskaya, Andrey A. Shuvalov, Vsevolod Аtkin, Andrey Zakharevich, Boris N. Khlebtsov, Julia S. Skibina, Pavel Ginzburg, Roman E. Noskov, Valery V. Tuchin and Dmitry A. Gorin
Materials 2019, 12(9), 1424; https://doi.org/10.3390/ma12091424 - 01 May 2019
Cited by 10 | Viewed by 3277
Abstract
Microstructured optical waveguides (MOW) are of great interest for chemical and biological sensing. Due to the high overlap between a guiding light mode and an analyte filling of one or several fiber capillaries, such systems are able to provide strong sensitivity with respect [...] Read more.
Microstructured optical waveguides (MOW) are of great interest for chemical and biological sensing. Due to the high overlap between a guiding light mode and an analyte filling of one or several fiber capillaries, such systems are able to provide strong sensitivity with respect to variations in the refractive index and the thickness of filling materials. Here, we introduce a novel type of functionalized MOWs whose capillaries are coated by a layer-by-layer (LBL) approach, enabling the alternate deposition of silica particles (SiO2) at different diameters—300 nm, 420 nm, and 900 nm—and layers of poly(diallyldimethylammonium chloride) (PDDA). We demonstrate up to three covering bilayers consisting of 300-nm silica particles. Modifications in the MOW transmission spectrum induced by coating are measured and analyzed. The proposed technique of MOW functionalization allows one to reach novel sensing capabilities, including an increase in the effective sensing area and the provision of a convenient scaffold for the attachment of long molecules such as proteins. Full article
(This article belongs to the Special Issue Design and Synthesis of Novel Optical Probes)
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15 pages, 48349 KiB  
Article
Design of an Integrated Optics Sensor Structure Based on Diamond Waveguide for Hemoglobin Property Detection
by Przemysław Struk
Materials 2019, 12(1), 175; https://doi.org/10.3390/ma12010175 - 07 Jan 2019
Cited by 4 | Viewed by 3772
Abstract
This manuscript presents a theoretical analysis of a diamond-based integrated optics structure for applications in biosensors. The geometrical, optical, and sensitivity properties of an integrated optical structure were theoretically analyzed and optimized for biosensor applications. The analysis focused on determining the waveguide properties, [...] Read more.
This manuscript presents a theoretical analysis of a diamond-based integrated optics structure for applications in biosensors. The geometrical, optical, and sensitivity properties of an integrated optical structure were theoretically analyzed and optimized for biosensor applications. The analysis focused on determining the waveguide properties, including the effective refractive index Neff as a function of refractive index nw and thickness dw of waveguide layer, refractive index of the hemoglobin cover layer ncH and substrate layer ns, homogeneous sensitivity dNeff/dncH, and modal field distribution of guided waveguide modes. The analysis was completed for two types of waveguide layer materials: undoped or boron-doped diamond films with or without the hemoglobin cover layer. The presented experimental results form a base for developing biosensor structures based on integrated optics for determining the properties of hemoglobin. Full article
(This article belongs to the Special Issue Design and Synthesis of Novel Optical Probes)
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