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Medicina
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Newest Pharmacodynamic Research in Pain Therapy
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Newest Pharmacodynamic Research in Pain Therapy

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2340

Special Issue Editor

Dr. Andrea Gažová

E-Mail Website
Guest Editor
Assistant Professor, Department of Pharmacology and Clinical Pharmacology, Comenius University Bratislava, Bratislava, Slovakia
Interests: pharmacology; clinical pharmacology; cardiovascular; neuronal system; orthopaedic

Special Issue Information

Dear Colleagues,

Pain is an unpleasant sensory and emotional experience associated with or resembling that associated with actual or potential tissue damage. Pain is always a personal experience influenced to varying degrees by biological, psychological, and social factors. We can divide the pain into acute and chronic pain.

The Definitions of acute and chronic pain can vary. The therapy can be divided too.

For acute pain, we can use NSAID or paracetamol, and for chronic pain are better paracetamol combined with tramadol or opioids drug. We use analgetics such as myorelaxant or antidepressant drugs. However, we have good medicine for the pain, and more people feel the pain all day of their life. This is why we must find a new mode of action of drugs or new drugs for the therapy of acute or chronic pain.

All the questions about pain can give us the answers, but it is more relevant than they give us the next questions.

We invite you to submit a paper for the journal Medicine for a special issue “Newest Pharmacodynamic Research in Pain Therapy” the topics of interest for this issue may include:

  • New drugs and their evaluation
  • New indication of drugs – pain therapy+
  • Cells therapy
  • New pharmacology combination of drug
  • The clinical study with NSAID, nonsteroidal analgetics, opioids
  • The preclinical experiments – new possibilities to treat pain
  • Other factors of pain (psychical)
  • Antidepressants for the treatment

Dr. Andrea Gažová
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • therapy of pain
  • new drugs
  • pharmacotherapy
  • innovative therapy
  • pharmacodynamic research
  • mode of action
  • non-pharmacology therapy
  • types of pain

Published Papers (2 papers)

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20 pages, 1052 KiB  
Article
The Influence of Sildenafil–Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice
by Ciprian Pușcașu, Anca Ungurianu, Oana Cristina Șeremet, Corina Andrei, Dragoș Paul Mihai and Simona Negreș
Medicina 2023, 59(8), 1375; https://doi.org/10.3390/medicina59081375 - 27 Jul 2023
Cited by 2 | Viewed by 1651
Abstract
Background and objectives: Worldwide, approximately 500 million people suffer from diabetes and at least 50% of these people develop neuropathy. Currently, therapeutic strategies for reducing diabetic neuropathy (DN)-associated pain are limited and have several side effects. The purpose of the study was [...] Read more.
Background and objectives: Worldwide, approximately 500 million people suffer from diabetes and at least 50% of these people develop neuropathy. Currently, therapeutic strategies for reducing diabetic neuropathy (DN)-associated pain are limited and have several side effects. The purpose of the study was to evaluate the antihyperalgesic action of different sildenafil (phosphodiesterase-5 inhibitor) and metformin (antihyperglycemic agent) combinations in alloxan-induced DN. Methods: The study included 100 diabetic mice and 20 non-diabetic mice that were subjected to hot and cold stimulus tests. Furthermore, we determined the influence of this combination on TNF-α, IL-6 and nitrites levels in brain and liver tissues. Results: In both the hot-plate and tail withdrawal test, all sildenafil–metformin combinations administered in our study showed a significant increase in pain reaction latencies when compared to the diabetic control group. Furthermore, all combinations decreased blood glucose levels due to the hypoglycemic effect of metformin. Additionally, changes in nitrite levels and pro-inflammatory cytokines (TNF-α and IL-6) were observed after 14 days of treatment with different sildenafil–metformin combinations. Conclusions: The combination of these two substances increased the pain reaction latency of diabetic animals in a dose-dependent manner. Moreover, all sildenafil–metformin combinations significantly reduced the concentration of nitrites in the brain and liver, which are final products formed under the action of iNOS. Full article
(This article belongs to the Special Issue Newest Pharmacodynamic Research in Pain Therapy)
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Article
Effects of Ibuprofen and Diclofenac Pre-Treatment on Viability and Apoptosis Processes in Human Dental Pulp Stem Cells
by Adriana Adamičková, Jan Kyselovic, Matúš Adamička, Nikola Chomaničová, Simona Valášková, Barbara Šalingová, Miroslava Molitorisová, Zdenko Červenák, Ľuboš Danišovič and Andrea Gažová
Medicina 2024, 60(5), 787; https://doi.org/10.3390/medicina60050787 - 9 May 2024
Viewed by 395
Abstract
Background and Objectives: Stem cell-based regeneration strategies have shown therapeutic efficacy in various fields of regenerative medicine. These include bone healing after bone augmentation, often complicated by pain, which is managed by using nonsteroidal anti-inflammatory drugs (NSAIDs). However, information is limited about [...] Read more.
Background and Objectives: Stem cell-based regeneration strategies have shown therapeutic efficacy in various fields of regenerative medicine. These include bone healing after bone augmentation, often complicated by pain, which is managed by using nonsteroidal anti-inflammatory drugs (NSAIDs). However, information is limited about how NSAIDs affect the therapeutic potential of stem cells. Materials and Methods: We investigated the effects of ibuprofen and diclofenac on the characteristics, morphology, and immunophenotype of human mesenchymal stromal cells isolated from the dental pulp (DPSCs) and cultured in vitro, as well as their effects on the expression of angiogenic growth factors (VEGFA and HGF) and selected genes in apoptosis signalling pathways (BAX, BAK, CASP3, CASP9, and BCL2). Results: Ibuprofen and diclofenac significantly reduced the viability of DPSCs, while the expression of mesenchymal stem cell surface markers was unaffected. Both ibuprofen and diclofenac treatment significantly upregulated the expression of HGF, while the expression of VEGFA remained unchanged. Ibuprofen significantly altered the expression of several apoptosis-related genes, including the upregulation of CASP9 and BCL2, with decreased CASP3 expression. BAK, CASP3, CASP9, and BCL2 expressions were significantly increased in the diclofenac-treated DPSCs, while no difference was demonstrated in BAX expression. Conclusions: Our results suggest that concomitant use of the NSAIDs ibuprofen or diclofenac with stem cell therapy may negatively impact cell viability and alter the expression of apoptosis-related genes, affecting the efficacy of stem cell therapy. Full article
(This article belongs to the Special Issue Newest Pharmacodynamic Research in Pain Therapy)
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