Endotheliopathy: Its Pathogenesis and Dysfunction Syndromes
A special issue of Medicina (ISSN 1648-9144).
Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 4499
Special Issue Editors
Interests: vascular biology; endothelial cell signalling; tumor angiogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The vascular endothelium forms the innermost layer of all blood vessels and has the vital task of providing nutrients to the underlying tissue while limiting the access of macromolecules and leukocytes. Loss of endothelial barrier function leads to life-threatening inflammatory diseases such as acute lung injury (ALI), deregulated angiogenesis, tumor angiogenesis, and vascular-associated diabetic retinopathy. Over time, the standard therapeutics of diseases caused due to endothelial cell (EC) dysfunction has evolved, which however has further the scope due to the conundrum of their off-target/on-target effects. There is an unmet need to understand the cellular and molecular aspects of EC-dysfunction-associated diseases that form the basis of their correct clinical understanding and pathology-based diagnostics. This Special Issue entitled “Endotheliopathy: Its Pathogenesis and Dysfunction Syndromes” focuses on EC injury and dysfunction with the aim of presenting an update of current understanding as well as the development of therapeutics and their implications. This will cover original/review/clinical/translational study papers related to the molecular mechanism of endothelial-dysfunction-associated diseases, diagnosis, and treatment.
Dr. Vijay Avin
Dr. Deborah Fratantonio
Guest Editors
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Keywords
- endothelial cells
- angiogenesis
- tumor-associated endothelial cells
- endothelial barrier dysfunction
- endothelial cell transition
- endothelial progenitor cells
- endothelial cell-targeted therapy
- pulmonary vascular injury
- brain vasculature
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