Prevention and Treatment of Gestational Diabetes

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 8243

Special Issue Editor


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Guest Editor
Department of Experimental Medicine, "Sapienza" University of Rome, 00185 Rome, Italy
Interests: endocrinology; metabolic diseases; type 2 diabetes; type 1 diabetes; gestational diabetes

Special Issue Information

Dear Colleagues,

The prevalence of gestational diabetes has significantly increased over the last few years, in line with the dramatic rise in obesity and type 2 diabetes. This condition significantly impacts maternal and fetal health, leading to short-term and long-term adverse outcomes for both mothers and their offspring.

The purpose of this Special Issue is to discuss different aspects of gestational diabetes, which might help to strengthen prevention and treatment strategies. Specifically, the role of emerging risk factors and novel biomarkers with potential diagnostic and prognostic utility will be examined, as well as the impact of both well-established and new therapeutic strategies on short- and long-term clinical outcomes of pregnancy complicated by gestational diabetes. Furthermore, developments in the understanding of the pathophysiological aspects of this condition will also be explored. Research articles, review articles, as well as short communications are invited.

Dr. Tiziana Filardi
Guest Editor

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Keywords

  • gestational diabetes risk
  • gestational diabetes prevention
  • gestational diabetes pathophysiology
  • novel diagnostic biomarkers for gestational diabetes
  • treatment strategies for gestational diabetes
  • maternal outcomes of gestational diabetes
  • fetal outcomes of gestational diabetes
  • long-term complications of gestational diabetes

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Published Papers (2 papers)

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Research

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12 pages, 1112 KiB  
Article
Prognostic Gene Predictors of Gestational Diabetes in Endometrium and Follicular Fluid of Women after Infertility
by Brigita Vaigauskaitė, Raminta Baušytė, Elvina Valatkaitė, Giedrė Skliutė, Edita Kazėnaitė, Diana Ramašauskaitė and Rūta Navakauskienė
Medicina 2022, 58(4), 498; https://doi.org/10.3390/medicina58040498 - 30 Mar 2022
Cited by 1 | Viewed by 2436
Abstract
Background and objectives. Gestational diabetes mellitus is an increasingly diagnosed metabolic disorder during pregnancy with unknown pathological pathways. Taking into account the growing numbers of women who are conceiving after assisted reproductive technologies, they comprise an engaging target group for gestational diabetes mellitus [...] Read more.
Background and objectives. Gestational diabetes mellitus is an increasingly diagnosed metabolic disorder during pregnancy with unknown pathological pathways. Taking into account the growing numbers of women who are conceiving after assisted reproductive technologies, they comprise an engaging target group for gestational diabetes mellitus etiopathogenesis research. In terms of metabolism and genetics, as the evidence shows, both unexplained infertility and gestational diabetes mellitus pose challenges for their interpretation due to the complex bodily processes. Materials and Methods. Our study examined the expression of genes (IGF2, GRB10, CRTC2, HMGA2, ESR1, DLK1, SLC6A15, GPT2, PLAGL1) associated with glucose metabolism in unexplained infertility patients who conceived after in vitro fertilization procedure, were diagnosed with GDM and their findings were compared with control population. Results. There were no significant differences in gene expression of endometrium stromal cells between healthy pregnant women and women with gestational diabetes, although the significant downregulation of CRTC2 was observed in the follicular fluid of women with gestational diabetes mellitus. Moreover, expression of HMGA2 and ESR1 was significantly reduced in FF cells when compared to endometrial cells. Conclusions. These findings may indicate about the importance of follicular fluid as an indicator for gestational diabetes and should be explored more by further research. Full article
(This article belongs to the Special Issue Prevention and Treatment of Gestational Diabetes)
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Review

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14 pages, 452 KiB  
Review
Negotiating Gestational Diabetes Mellitus in India: A National Approach
by Uday Thanawala, Hema Divakar, Rajesh Jain and Mukesh M. Agarwal
Medicina 2021, 57(9), 942; https://doi.org/10.3390/medicina57090942 - 6 Sep 2021
Cited by 10 | Viewed by 5197
Abstract
The worldwide epidemic of diabetes mellitus and hyperglycemia in pregnancy (HIP) presents many challenges, some of which are country-specific. To address these specific problems, parochial resolutions are essential. In India, the government, by working in tandem with (a) national groups such as the [...] Read more.
The worldwide epidemic of diabetes mellitus and hyperglycemia in pregnancy (HIP) presents many challenges, some of which are country-specific. To address these specific problems, parochial resolutions are essential. In India, the government, by working in tandem with (a) national groups such as the Diabetes in Pregnancy Study Group of India, and (b) global organizations such as the International Diabetes Federation, has empowered the medical and paramedical staff throughout the country to manage HIP. Additionally, despite their academic university backgrounds, Indian health planners have provided practical guidelines for caregivers at the ground level, who look up to these experts for guidance. This multipronged process has helped to negotiate some of the multiple problems that are indigenous and exclusive to India. This review traces the Indian journey to manage and prevent HIP with simple, constructive, and pragmatic solutions. Full article
(This article belongs to the Special Issue Prevention and Treatment of Gestational Diabetes)
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