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Medicina
Special Issues
Gastroesophageal Reflux Disease and Esophageal Motility Disorders
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Gastroesophageal Reflux Disease and Esophageal Motility Disorders

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1896

Special Issue Editor

Dr. Almantas Maleckas

E-Mail Website
Guest Editor
1. Department of Gastrosurgical Research and Education, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
2. Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: surgery of GERD and esophageal motility disorders; minimally invasive esophageal and gastric surgery; esophageal carcinoma; gastric carcinoma; bariatric surgery; metabolic surgery

Special Issue Information

Dear Colleagues,

Gastroesophageal reflux disease (GERD) and esophageal motility disorders are benign conditions that have significant impacts on quality of life. The prevalence of GERD is high in the general population and treatment may vary from pharmacological acid suppression to surgical intervention if hiatal hernia is present. The treatment of PPI-resistant GERD is debatable, and surgery can be offered if GERD symptoms are recalcitrant, including pronounced regurgitation. Barrett esophagus is a severe complication of chronic GERD. The endoscopic surveillance of Barrett esophagus is essential for the early detection of dysplasia and adenocarcinoma. Minimally invasive nonendoscopic diagnostic tools are currently being developed, and the main treatment is endoscopic resection and ablation. Obesity is an important risk factor for the development of GERD and GERD-related complications. The impact of weight loss procedures on existing GERD or de novo GERD are still under investigation. High-resolution manometry is key to diagnosing primary esophageal motility disorders, but their pathogenesis is still mysterious and classification is based on changes in motility rather than histological characteristics. The most common esophageal motility disorder is achalasia. The treatment is concentrated on reducing resistance to outflow in the lower esophageal sphincter by different medical and surgical therapies. Another important aspect is the treatment after failed surgical procedures performed for GERD or achalasia. More data about diagnostics and repeated surgical interventions are needed.

This Special Issue aims to present current trends in the diagnosis and treatment of GERD and esophageal motility disorders. We welcome the submission of cutting-edge research on topics including the long-term effects of GERD treatment with PPIs and surgical procedures, newer minimally invasive modalities in GERD treatment, nonendoscopic diagnostics of Barrett esophagus, results of the endoscopic treatment of Barrett esophagus, the impact of weight loss surgery on GERD, the pathogenesis of esophageal motility disorders, and the diagnosis and treatment of GERD and esophageal motility disorders after failed surgical interventions. We are soliciting original research and review articles.

Dr. Almantas Maleckas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastroesophageal reflux disease
  • esophageal motility disorders
  • Barrett esophagus
  • achalasia
  • obesity

Published Papers (2 papers)

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Research

9 pages, 1185 KiB  
Article
Impact of Age on Long-Term Outcomes of Laparoscopic Nissen Fundoplication—A Single Center Study
by Natalia Dowgiałło-Gornowicz, Justyna Kacperczyk, Anna Masiewicz, Karolina Osowiecka and Paweł Lech
Medicina 2024, 60(5), 688; https://doi.org/10.3390/medicina60050688 - 24 Apr 2024
Viewed by 701
Abstract
Background and objectives: Gastroesophageal reflux disease (GERD) is a common disease affecting approximately 20% of the adult population. This study aimed to compare the results of laparoscopic Nissen fundoplication (LNF) in the treatment of GERD in patients of different age groups. Materials and [...] Read more.
Background and objectives: Gastroesophageal reflux disease (GERD) is a common disease affecting approximately 20% of the adult population. This study aimed to compare the results of laparoscopic Nissen fundoplication (LNF) in the treatment of GERD in patients of different age groups. Materials and Methods: A retrospective analysis was performed on patients who underwent LNF in one surgical department between 2014 and 2018. Patients were divided into three groups based on age: under 40 years of age, 40–65 years of age, and over 65 years of age. Results: A total of 111 patients (44.1% women) were analyzed in this study. The mean age was 50.2 ±15 years, and the mean follow-up was 50 months ± 16.6 months. Recurrence of symptoms occurred in 23%, 20%, and 23% in each age group, respectively (p = 0.13), and 85%, 89%, and 80% of patients from the respective groups reported that they would recommend the surgery to their relatives (p = 0.66). Furthermore, 83%, 92%, and 73% of patients from the respective age groups reported that they would undergo the surgery again with the knowledge they now had (p = 0.16). Conclusions: Given these results and observations, LNF has been shown to be a good method of treatment for GERD in every age group. In our study, there were no differences found in terms of satisfaction with surgery and associated recommendations between the studied age groups. Full article
(This article belongs to the Special Issue Gastroesophageal Reflux Disease and Esophageal Motility Disorders)
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10 pages, 1025 KiB  
Article
A Three-Arm Randomized Controlled Trial of Primary One-Anastomosis Gastric Bypass: With FundoRing or Nissen Fundoplications vs. without Fundoplication for the Treatment of Obesity and Gastroesophageal Reflux Disease
by Oral Ospanov, Nurlan Zharov, Bakhtiyar Yelembayev, Galymjan Duysenov, Irina Volchkova, Kassymkhan Sultanov and Adil Mustafin
Medicina 2024, 60(3), 405; https://doi.org/10.3390/medicina60030405 - 27 Feb 2024
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Abstract
Background and Objectives: Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. The purpose of this study is to compare bariatric and antireflux results after OAGB with [...] Read more.
Background and Objectives: Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. The purpose of this study is to compare bariatric and antireflux results after OAGB with different methods of fundoplication using the excluded stomach and without fundoplication. Materials and methods: This open-label, randomized, parallel three-arm trial was conducted from March 2019 and December 2021. All patients underwent laparoscopic one-anastomosis gastric bypass and suture cruroplasty, and then had a follow-up at 24 months. Group 1 of patients had fundoplication FundoRing using the excluded stomach (FundoRingOAGB); Group 2, with Nissen fundoplication using the excluded stomach (NissenOAGB); and Group 3, without fundoplication (OAGB). We studied changes in BMI, GERD symptoms (GERD-HRQL), and the VISICK score. Results: Of 219 participants screened, 150 were randomly allocated to 3 groups: FundoRingOAGB group (n = 50), NissenOAGB group (n = 50), and OAGB group (n = 50). At post-treatment month 24, BMI changes were as follows: from 40.7 ± 5.9 (31–53) to 24.3 ± 2.8 (19–29) kg/m2 in FundoRingOAGB group; from 39.9 ± 5.3 (32–54) to 26.3 ± 2.9 (23–32) kg/m2 in Nissen group; and from 40.9 ± 6.2 (32–56) to 28.5 ± 3.9 (25–34) kg/m2 in OAGB group. The mean pre-operative GERD-HRQL heartburn score improved post-op in FundoRingOAGB group from 20.6 ± 2.24 (19.96, 21.23) to 0.44 ± 0.73 (0.23, 0,64); in NissenOAGB group from 21.34 ± 2.43 (20.64, 22.03) to 1.14 ± 1.4 (0.74, 1.53); and in OAGB group 20.5 ± 2.17 (19.9, 21.25) to 2.12 ± 1.36 (1.73, 2.5). GERD-HRQL total scores were from pre-op 25.2 ± 2.7 (24.4, 25.9) to 4.34 ± 1.3 (3.96, 4.7) post-op in FundoRingOAGB group; 24.8 ± 2.93 (24, 25.67) pre-op to 5.42 ± 1.7 (4.9, 5.9) in the NissenOAGB group; and from 21.46 ± 2.7 (20.7, 22.2) to 7.44 ± 2.7 (6.6, 8.2) in the OAGB group. The mean VISICK score improved from 3.64 ± 0.94 (3.7, 3.9) to 1.48 ± 1.26 (1.12, 1.84) in FundoRingOAGB, from 3.42 ± 0.97 (3.1, 3,7) to 2.5 ± 1.46 (2.06, 2.9) in NissenOAGB group and from 3.38 ± 0.88 (3.1, 3,69) to 2.96 ± 1.19 (2.62, 3.2) in OAGB group. Conclusions: Antireflux and bariatric results of FundoRingOAGB are better than using the NissenOAGB method and significantly better than OAGB without the use of fundoplication. Full article
(This article belongs to the Special Issue Gastroesophageal Reflux Disease and Esophageal Motility Disorders)
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