Advancement of Microbiome and Metabolomics in Understanding Immune Homeostasis

Dear Colleagues,

The intricate interplay between gut microbiome and host metabolic landscape is pivotal in orchestrating immune responses. This Special Issue, entitled “Advancement of Microbiome and Metabolomics in Understanding Immune Homeostasis”, aims to shed light on the intricate relationships between gut ecology, microbiome, metabolome, and their collective impact on immune regulation and responses.

Focus:

• Exploration of the role of gut microbial communities and their metabolomic profiles in modulating immune responses.
• Investigating the role of the microbiome and metabolome in maintaining immune homeostasis and their implications in disease and transplantation.
• Computational biology approaches for deciphering complex microbe–immunity interactions and their systemic effects.

This Special Issue is dedicated to exploring the latest advancements in microbiome research and metabolomics, particularly their combined impact on immune homeostasis. Emphasis will be placed on original research and reviews that unveil new insights into gut ecology, revealing how microbial diversity and metabolic pathways influence the immune system behavior in health and disease.

Scope:

Contributions should focus on, but are not limited to, the study of gut microbial communities, their metabolomic outputs, and the resultant effects on immune responses. This includes computational biology approaches to decipher complex microbe–immunity interactions, the role of the microbiome in T cell differentiation and regulation, and insights into alloimmune responses in the context of solid organ transplants. Studies that leverage cutting-edge technologies to dissect these interactions, such as single-cell RNA sequencing, spatial transcriptome, integrative microbiome-metabolome modeling, or advanced metabolomic analyses, are particularly welcome.

Purpose:

The goal of this Special Issue is to build an advanced understanding of the role of the microbiome and metabolites in maintaining immune equilibrium. This Issue seeks to provide a platform for interdisciplinary collaboration, drawing together experts from diverse fields to foster a holistic understanding of the microbiome–metabolome–immune axis.

Dr. Bing Ma
Dr. Young Suk Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• microbiome
• metabolite
• immune homeostasis
• host–microbe interaction
• integrative multi-omics
• microbial ecology
• T cell differentiation
• regulation