Lipidomic Signatures in Pediatric Metabolic Disorders

Dear Colleagues,

Lipids play critical roles in structural compartmentalization (barrier function), energy storage, and signal transduction, serving as key pathophysiological mediators that regulate intracellular functions, comprising apoptosis, inflammation, proliferation, and response to stress. Today, dyslipidemia is associated with multiple congenital metabolic diseases with multidisciplinary clinical appearances, including ophthalmological, neurological, renal, dermatological, orthopedic, skeletal, immune, and hepatic presentations. New lipidomic technologies and studies will allow for the identification of rare diseases in the next few years.

In recent years, different pathologies have been raised in children in industrialized countries, making the pediatric population the subject of new lines of research for understanding subsequent treatment options for providing patients with a better quality of life in the future. Some of the studied pathologies are diabetes, non-alcoholic fatty liver, and obesity. Lifestyle and dietary changes are influencing the development of these pathologies. However, other rare metabolic disorders that could not be considered in previous years are also being studied, though their metabolic pathways could be assessed based on the recent advances in analytical techniques, such as lipidomic analysis performed via mass spectrometry.

The scope of this Special Issue “Lipidomic Signatures in Pediatric Metabolic Disorders” covers topics that include lipidomic studies of the pediatric population, which can comprise, but are not limited to, new analyses, profiling, and therapies that affect and involve lipids.     

Dr. Mónica Narváez-Rivas
Guest Editor

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• lipidomics
• lipids
• mass spectrometry
• pediatric population
• therapeutic targets
• biomarkers
• metabolic disorder