Metabolomic in Chronic Disease

Dear Colleagues,

Chronic diseases, including cardiovascular diseases, diabetes, cancer and neurological disorders such as Alzheimer’s disease and depression, are the leading cause of disability and death in most countries, posing significant challenges to global public health. Additionally, since the outbreak of the COVID-19 pandemic, there has been an increasing recognition of the prevalence and severity of chronic sequelae following acute viral infections. The estimated worldwide economic cost of “long COVID”, attributed to the lost quality of life, earnings and increased medical expenses, amounts to USD 3.7 trillion in total. As such, there is a pressing need to better understand the pathogeneses of various chronic diseases, and to advance progress in the development of preventive strategies and precise therapeutic measures.

Chronic diseases are often heterogeneous and the heterogeneity manifests across multiple levels, from genotype through molecular and cellular compartments to the phenotype, outcome and response to treatment. Metabolomic targets represent downstream products of the biological processes involved in gene–environment interactions and, thanks to the rapid technological advancements, have emerged as a powerful tool in medical research on complex chronic diseases.

This Special Issue focuses on the clinical implications of metabolomic analyses, including multi-omics integrative analyses, on the diagnoses, pathogeneses, prognoses and treatment of chronic diseases. Original research articles, reviews and short communications from researchers across disciplines are welcome. We also encourage groundbreaking work on technological advancements and data analysis techniques in metabolomics.

Dr. Xiaoyu Che
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolomics
• chronic diseases
• multi-omics
• bioinformatics
• biomarker discovery
• system biology