Metabolites, Neutrophil Metabolism and Effector Functions

Dear Colleagues,

Neutrophils, the most abundant leukocytes in human blood, are at the front line of defence against bacterial infections, with an estimated turnover rate of about 10¹¹ cells per day and a relatively short half-life in circulation. They sense infection as well as tissue damage, and rapidly mobilize toward compromised zones. Neutrophils are highly glycolytic cells, and perhaps for this reason, it was thought at some point that these cells contain few mitochondria or non-functional mitochondria. It is currently known that neutrophil mitochondria are indeed functional and have an active role in several neutrophil effector functions, including phagocytosis, bactericidal activity and NET formation. Neutrophils may be exposed to different microenvironments during their lifetime, including bone marrow, both while differentiating and exiting, and when they return as dying cells, blood circulation, solid tumours, infected tissues, etc. An outstanding question is how different metabolites reprogram neutrophil mitochondria and in turn fine-tune neutrophil function. This topic explores just that, from basic mechanisms to possible clinical interventions.

Prof. Dr. Francisco Javier Sánchez-García
Guest Editor

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• innate immunity
• infection
• neutrophils
• metabolism
• cell signaling
• metabolic microenvironment