Profiling of Bone Marrow Adipose Tissue Cells and Metabolism

Dear Colleagues,

Bone marrow adipose tissue (BMAT) represents a metabolically unique adipose depot within the skeletal system. BMAT interacts with other bone marrow niches, affecting hematopoietic and skeletal system health. The adipogenic differentiation of subsets of adipocytic progenitors within bone marrow is coupled with a set of metabolic and bioenergetic changes in bone marrow niche cells. Being responsive to nutritional, environmental, and hormonal stimuli, bone marrow adipocytes have important endocrine and metabolic roles that can overcome the bone marrow niche. A postnatal increase in human BMAT occurs during aging, and its overexpansion can be associated with the progression of obesity, diabetes, skeletal diseases, and malignancies. However, we still do not understand the molecular background of BMAT maintenance and expansion, nor the metabolic reprogramming that leads to the establishment of an undesirable BMAT phenotype.

Revealing the metabolic reprogramming involved in the cellular identity of BMAT can contribute to novel strategies for the improvement of human health during aging and with pathologies. For this, new approaches defining the metabolic profile of BMAT at the cellular and molecular levels are required. This Special Issue will include research articles and reviews that aim to elucidate BMAT cell metabolism in aging and diseases.

Dr. Drenka Trivanovic
Dr. Nina Krako Jakovljević
Guest Editors

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• bone marrow adipose tissue
• adipocytes
• mitochondria
• lipids
• nutrition
• cancer
• hematopoiesis
• skeletal system
• aging