Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome

Dear Colleagues,

In the face of escalating global health challenges, the intricate web linking obesity, diabetes, and metabolic syndrome has emerged as a forefront concern for researchers, clinicians, and public health policymakers. This Special Issue of Metabolites aims to delve into the complexities of these interrelated conditions, with a specific focus on unraveling their pathogenesis. By casting a spotlight on the root causes and mechanisms underlying these diseases, we aspire to foster a deeper understanding that could eventually pave the way for innovative prevention and treatment strategies.

The epidemic proportions of obesity and its consequent cascade effect—propelling the rise in type 2 diabetes and metabolic syndrome instances worldwide—necessitate a multifaceted examination. This pursuit is not merely academic; it has the potential to significantly alter the course of countless lives through informed intervention strategies and therapeutic advancements.

We invite contributors to explore a broad spectrum of topics within this theme, including, but not limited to, the following:

1. Genetic predispositions and molecular biological insights into obesity, diabetes, and metabolic syndrome.
2. The impact of lifestyle factors (diet, physical activity, sleep, and stress) on the manifestation and progression of these diseases.
3. The role of the microbiome and environmental exposures in disease pathogenesis.
4. The potential of multi-omics in uncovering novel pathways and targets, such as metabolomics, lipidomics, proteomics, genomics, etc.
5. The role of inflammation and oxidative stress in these metabolic diseases.
6. Pathophysiological mechanisms about how obesity, diabetes, and metabolic syndrome interact and potentiate each other.

This Special Issue aims to be a crucible of innovation, gathering under its aegis the latest research findings, insightful reviews, and forward-thinking perspectives. Our goal is to inspire a cross-disciplinary dialogue that spans the spectrum from molecular biology to societal interventions, weaving together a comprehensive narrative on the pathogenesis of obesity, diabetes, and metabolic syndrome.

We welcome submissions in the form of original research articles, clinical trials, reviews, and perspectives that contribute meaningfully to our understanding of these conditions and offer glimpses into future directions for research and application. Contributions should aim not only to map the current landscape but also to identify gaps in our knowledge and propose pathways towards solutions.

Together, through this Special Issue, let us create a collaborative platform for sharing cutting-edge research and innovative ideas, igniting conversations that could lead to groundbreaking transformations in how these pervasive health issues are understood and addressed. Submissions are now open; we look forward to receiving contributions that enrich this critical discourse.

Prof. Dr. Tiemin Liu
Dr. Hongmei Yan
Dr. Qiongyue Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolic diseases: obesity, diabetes, NAFLD, MAFLD, NASH, metabolic syndrome, etc.
• multi-omics: metabolomics, lipidomics, proteomics, etc.
• pathogenesis: genetic predispositions, lifestyle factors, microbiome and environmental exposures, etc.