Metabolomic Insights: Interplay between Metabolism and Immune Response in Cancer

Dear Colleagues,

Understanding the interplay between metabolism and the immune response in cancer is crucial for developing effective therapeutic strategies. Metabolomics, which involves the comprehensive analysis of small molecules (metabolites) within biological systems, offers a holistic view of cellular metabolism and its regulation in the context of cancer and the immune system.

In cancer, dysregulated metabolism is a hallmark feature, with altered nutrient uptake, energy production, and metabolite utilization, supporting tumor growth and progression. The immune system plays a pivotal role in cancer surveillance and defense, with immune cells capable of recognizing and eliminating cancerous cells. However, tumors often develop mechanisms to evade immune detection and suppress immune responses, creating an immunosuppressive microenvironment that facilitates tumor growth and metastasis. Metabolomic studies have uncovered intricate interactions between cancer metabolism and immune function, offering insights into the potential therapeutic targets and biomarkers.

The intention of this Special Issue is the enrichment and evolution of this research field pertaining to the interplay between metabolism and the immune response in cancer. We are pleased to invite clinicians and researchers to submit any relevant scientific work to this interesting and promising Special Issue of Metabolites.

We look forward to your contributions.

Dr. Dimitra Rafailia Bakaloudi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolites
• metabolism
• cancer
• immune response
• immunotherapy
• immunometabolism