New Insights on the Role of Lipid Metabolism in the Development of Cardiac Dysfunction

Dear Colleagues,

Myocardial lipid metabolism remains of critical importance in the resynthesis of ATP and maintenance of contraction in the healthy heart. However, lipid metabolism is suggested as a culprit mechanism in the development of cardiac dysfunction in a variety of chronic diseases such as pressure-overload hypertrophy, diabetes, obesity, and heart failure. Excessive fatty acid oxidation, decreased fatty acid oxidation, “lipotoxicity”, and changes in other lipid metabolic pathways have been implicated as potential causes of cardiac dysfunction. However, the distinguishing metabolic aberrancy in lipid metabolism could be distinct to specific pathologies or populations.     

This Special Issue of Metabolites will be dedicated to publishing original articles and reviews that provide insight into the role of alterations in myocardial lipid metabolism that contribute to the development of cardiac dysfunction. We welcome the submission of original studies or review articles that highlight changes in lipid metabolism that are the cause or consequence of cardiac dysfunction in specific pathologies. In addition, studies and papers seeking to identify changes in lipid metabolism that contribute to differences in sex, race/ethnicity, and aging will be of particular interest.   

Dr. Stephen C. Kolwicz
Guest Editor

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