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Metabolites
Special Issues
RNA Metabolism and Human Diseases
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RNA Metabolism and Human Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1912

Special Issue Editors

Prof. Dr. Tangliang Li

E-Mail Website
Guest Editor
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China
Interests: nonsense-mediated mRNA decay; stem cell biology; neurodevelopmental disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hua Jin

E-Mail Website
Guest Editor
Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Beijing 100081, China
Interests: RNA modification; RNA-binding protein; noncoding RNA; genetic disease

Special Issue Information

Dear Colleagues,

RNA metabolism involves a series of molecular events during the whole lifespan of RNAs, including transcription, pre-mRNA processing, epitranscriptomic modification, translation, and RNA degradation. These processes are tempo-spatially controlled by various proteins such as RNA-binding proteins and RNA-related enzymes, and also by noncoding RNAs, such as microRNAs, siRNAs, piRNAs, long noncoding RNAs, and circular RNAs, in different cellular compartments accompanying a variety of life activities. Disturbances of RNA metabolism are strongly associated with human developmental disorders, cancers, viral infection, and aging processes. In this Special Issue entitled “RNA Metabolism and Human Diseases”, we invite you to submit original articles or reviews discussing the biological consequences and molecular mechanisms of any aspects of RNA metabolism in models of cells, animals, and humans. We hope this Special Issue will provide a valuable platform for scientific communication among researchers working on RNA biology.

Prof. Dr. Tangliang Li
Prof. Dr. Hua Jin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA metabolism
  • RNA processing
  • epitranscriptome
  • translational control
  • RNA degradation
  • developmental disorders
  • cancer
  • aging
  • viral infection
  • RNA-binding proteins
  • RNA-related enzymes
  • noncoding RNAs

Published Papers (1 paper)

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Review

14 pages, 1745 KiB  
Review
The Battle for Survival: The Role of RNA Non-Canonical Tails in the Virus–Host Interaction
by Xianghui Wen, Ahsan Irshad and Hua Jin
Metabolites 2023, 13(9), 1009; https://doi.org/10.3390/metabo13091009 - 13 Sep 2023
Viewed by 1200
Abstract
Terminal nucleotidyltransferases (TENTs) could generate a ‘mixed tail’ or ‘U-rich tail’ consisting of different nucleotides at the 3′ end of RNA by non-templated nucleotide addition to protect or degrade cellular messenger RNA. Recently, there has been increasing evidence that the decoration of virus [...] Read more.
Terminal nucleotidyltransferases (TENTs) could generate a ‘mixed tail’ or ‘U-rich tail’ consisting of different nucleotides at the 3′ end of RNA by non-templated nucleotide addition to protect or degrade cellular messenger RNA. Recently, there has been increasing evidence that the decoration of virus RNA terminus with a mixed tail or U-rich tail is a critical way to affect viral RNA stability in virus-infected cells. This paper first briefly introduces the cellular function of the TENT family and non-canonical tails, then comprehensively reviews their roles in virus invasion and antiviral immunity, as well as the significance of the TENT family in antiviral therapy. This review will contribute to understanding the role and mechanism of non-canonical RNA tailing in survival competition between the virus and host. Full article
(This article belongs to the Special Issue RNA Metabolism and Human Diseases)
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