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Journals
Microorganisms
Special Issues
Implant and Prosthetic Infections
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Implant and Prosthetic Infections

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 5920

Special Issue Editor

Dr. Lorenzo Drago

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Guest Editor
Department of Biochemical Sciences for Health, University of Milan, Milan, Italy
Interests: microbiota and probiotics; prosthetic and joint infections; biofilm implant related infections; osteomyelitis; diagnosis for bone-joint infections; antimicrobials and antimicrobial devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Orthopedic infections are common and devastating issues in the clinical setting. Prosthetic and orthopedic infections are often neglected by the scientific community, but their incidence is increasing and these types of infections are difficult to treat. Diagnostics tools are often not correctly applied and antibiotic treatments fail because of the increased incidence of bacterial resistance or the presence of biofilms that are able to protect the pathogens. Infections, especially iatrogenic and nosocomial infections, are receiving increasing attention and visibility because of the high rate of litigation involving them and their very negative outcomes for patients. A prompt and true diagnosis is essential at any level of suspicion of infection to avoid delay of medical or surgical treatment. For this reason, infection prevention, recognition, and prompt attention are of paramount importance. Accurate diagnosis remains difficult, as most signs of infection are subjective, so a multidisciplinary approach is necessary to improve the diagnosis and treatment success of these challenging infections.

Prof. Dr. Lorenzo Drago
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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19 pages, 726 KiB  
Article
The Main Bacterial Communities Identified in the Sites Affected by Periimplantitis: A Systematic Review
by Simina Angela Lăcrimioara Iușan, Ondine Patricia Lucaciu, Nausica Bianca Petrescu, Ioana Codruța Mirică, Dan-Alexandru Toc, Silviu Albu and Carmen Costache
Microorganisms 2022, 10(6), 1232; https://doi.org/10.3390/microorganisms10061232 - 16 Jun 2022
Cited by 8 | Viewed by 2053
Abstract
(1) Background: Periimplantitis is an infectious condition that affects the periimplant tissue and is of bacterial etiology. However, to date, the exact bacterial flora involved in its occurrence is not known. The aim of this literature review was to summarize the articles published [...] Read more.
(1) Background: Periimplantitis is an infectious condition that affects the periimplant tissue and is of bacterial etiology. However, to date, the exact bacterial flora involved in its occurrence is not known. The aim of this literature review was to summarize the articles published on this topic and to identify the main bacterial species isolated in periimplantitis. (2) Methods: The articles published in three databases were researched: Pubmed, Embase and Web of Science using Prisma guides and combinations of MeSH terms. We selected 25 items from the 980 found by applying the inclusion and exclusion criteria. (3) Results: We quantified the results of the 25 studies included in this review. In general, the most commonly identified bacterial species were Gram-negative anaerobic species, as Prevotella, Streptococcus, Fusobacterium and Treponema. (4) Conclusion: The most frequent bacteria in the periimplantitis sites identified in this review are Gram-negative anaerobic species, also involved in the pathogenesis of the periodontal disease. Full article
(This article belongs to the Special Issue Implant and Prosthetic Infections)
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Review

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37 pages, 897 KiB  
Review
A Journey into Animal Models of Human Osteomyelitis: A Review
by Gabriele Meroni, Alexios Tsikopoulos, Konstantinos Tsikopoulos, Francesca Allemanno, Piera Anna Martino and Joel Fernando Soares Filipe
Microorganisms 2022, 10(6), 1135; https://doi.org/10.3390/microorganisms10061135 - 31 May 2022
Cited by 11 | Viewed by 3385
Abstract
Osteomyelitis is an infection of the bone characterized by progressive inflammatory destruction and apposition of new bone that can spread via the hematogenous route (hematogenous osteomyelitis (HO)), contiguous spread (contiguous osteomyelitis (CO)), and direct inoculation (osteomyelitis associated with peripheral vascular insufficiency (PVI)). Given [...] Read more.
Osteomyelitis is an infection of the bone characterized by progressive inflammatory destruction and apposition of new bone that can spread via the hematogenous route (hematogenous osteomyelitis (HO)), contiguous spread (contiguous osteomyelitis (CO)), and direct inoculation (osteomyelitis associated with peripheral vascular insufficiency (PVI)). Given the significant financial burden posed by osteomyelitis patient management, the development of new preventive and treatment methods is warranted. To achieve this objective, implementing animal models (AMs) of infection such as rats, mice, rabbits, avians, dogs, sheep, goats, and pigs might be of the essence. This review provides a literature analysis of the AMs developed and used to study osteomyelitis. Historical relevance and clinical applicability were taken into account to choose the best AMs, and some study methods are briefly described. Furthermore, the most significant strengths and limitations of each species as AM are discussed, as no single model incorporates all features of osteomyelitis. HO’s clinical manifestation results in extreme variability between patients due to multiple variables (e.g., age, sex, route of infection, anatomical location, and concomitant diseases) that could alter clinical studies. However, these variables can be controlled and tested through different animal models. Full article
(This article belongs to the Special Issue Implant and Prosthetic Infections)
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