Advances in Human Microbiomes

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 855

Special Issue Editor


E-Mail Website
Guest Editor
Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark
Interests: human microbiome; microbiota; dysbiosis; gut microbiota; host-microbiome interactions

Special Issue Information

Dear Colleagues,

The human microbiome has important functions and roles in their hosts and is tightly connected to human health and disease. Numerous studies have demonstrated imbalances in microbiota composition between patients and healthy controls, and further in vitro and animal studies have highlighted the functional impact of the microbiome on disease development or symptom maintenance. This has attracted great interest in targeting the human microbiome for therapeutical purposes. Current strategies include diet interventions, intake of pre- and probiotics or fecal microbiota transplantation, where the latter has proven highly effective for the treatment of recurrent C. difficile infections. Other effective curative or symptom-reducing options have proven more challenging, despite extensive mapping and thorough characterization of the human microbiome. This indicates that researchers still need to obtain a greater understanding of how the microbiome communicates and interacts with host cells or organs, and further identify which factors are important for shifts in microbiota composition. 

MDPI’s Microorganisms announces the launch of the Special Issue entitled “Advances in Human Microbiomes”. We invite submissions of manuscripts and research articles (original and review articles) addressing the direct interactions between human microbiomes and their hosts, and on the factors involved in microbiome community structure. The goal of this Special Issue is to enhance our current understanding and advancements in the field of microbiome–host communication research and based on this discuss future therapeutic possibilities.

This Special Issue will focus on the communication between a healthy or dysbiotic human microbiome and host cells or organs, and on microbiome community structure. We welcome all studies that help pave the way for new and improved microbiota-targeting therapeutics.

Dr. Suzette Sørensen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human microbiome
  • microbiota
  • dysbiosis
  • therapeutics
  • microbiome–host communication

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 4661 KiB  
Article
Identification of the Microbiome Associated with Prognosis in Patients with Chronic Liver Disease
by Kenta Yamamoto, Takashi Honda, Yosuke Inukai, Shinya Yokoyama, Takanori Ito, Norihiro Imai, Yoji Ishizu, Masanao Nakamura and Hiroki Kawashima
Microorganisms 2024, 12(3), 610; https://doi.org/10.3390/microorganisms12030610 - 19 Mar 2024
Viewed by 695
Abstract
We investigated the prognostic role of the gut microbiome and clinical factors in chronic liver disease (hepatitis, cirrhosis, and hepatocellular carcinoma [HCC]). Utilizing data from 227 patients whose stool samples were collected over the prior 3 years and a Cox proportional hazards model, [...] Read more.
We investigated the prognostic role of the gut microbiome and clinical factors in chronic liver disease (hepatitis, cirrhosis, and hepatocellular carcinoma [HCC]). Utilizing data from 227 patients whose stool samples were collected over the prior 3 years and a Cox proportional hazards model, we integrated clinical attributes and microbiome composition based on 16S ribosomal RNA sequencing. HCC was the primary cause of mortality, with the Barcelona Clinic Liver Cancer staging system-derived B/C significantly increasing the mortality risk (hazard ratio [HR] = 8.060; 95% confidence interval [CI]: 3.6509–17.793; p < 0.001). Cholesterol levels < 140 mg/dL were associated with higher mortality rates (HR = 4.411; 95% CI: 2.0151–9.6555; p < 0.001). Incertae sedis from Ruminococcaceae showed a protective effect, reducing mortality risk (HR = 0.289; 95% CI: 0.1282 to 0.6538; p = 0.002), whereas increased Veillonella presence was associated with a higher risk (HR = 2.733; 95% CI: 1.1922–6.2664; p = 0.017). The potential of specific bacterial taxa as independent prognostic factors suggests that integrating microbiome data could improve the prognosis and treatment of chronic liver disease. These microbiome-derived markers have prognostic significance independently and in conjunction with clinical factors, suggesting their utility in improving a patient’s prognosis. Full article
(This article belongs to the Special Issue Advances in Human Microbiomes)
Show Figures

Figure 1

Back to TopTop