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Chemical and Biological Research on Bioactive Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1257

Special Issue Editor


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Guest Editor
Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan
Interests: natural product chemistry; bioactive natural products; new drug R&D; translation research; cosmetic and functional food R&D; Chinese herbal medicine biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will provide an intellectual platform for scientists to publish reviews, original research, short communications, etc., on bioactive natural products (NPs), biological activities, and analytical methodologies in relation to natural sources (medicinal plants, fungi…), as well as related topics of interest to public health.

Bioactive natural products isolated from various sources, especially plants and fungi, have long been used to treat human diseases. Developing new drugs through natural products has long proven to be the most successful strategy for discovering new treatments. NPs have historically been a crucial source of drugs, and are still considered a beneficial starting point in modern drug discovery, providing critical contributions to pharmacotherapy in many human diseases. NPs are characterized by structural complexity and skeletal diversity; thus, they continue to be an important source of information about new drugs.

This Special Issue of Molecules aims to highlight the natural products in lead compound and drug discovery, with particular focus on the isolation and structure elucidation of new natural products, the mechanism of action, and bioactive compounds with clinical potential. Original research and reviews on the preparation and identification of phytochemicals and their physiological mechanisms in health benefits are welcome.

Prof. Dr. Jih-Jung Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • medicinal plants
  • drug discovery
  • bioactive constituent
  • biological activity
  • healthy food
  • drug and herbal medicine
  • mechanism of action

Published Papers (1 paper)

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Research

12 pages, 5330 KiB  
Article
In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1
by Mohammed Kaleem, Asaad Kayali, Ryan A. Sheikh, Abudukadeer Kuerban, Mohammed A. Hassan, Naif Abdullah R. Almalki, Fahad A. Al-Abbasi, Firoz Anwar, Ziad Omran and Mahmoud Alhosin
Molecules 2024, 29(2), 434; https://doi.org/10.3390/molecules29020434 - 16 Jan 2024
Cited by 1 | Viewed by 1057
Abstract
Breast cancer (BC) is one of the most common cancers in women and is a major cause of female cancer-related deaths. BC is a multifactorial disease caused by the dysregulation of many genes, raising the need to find novel drugs that function by [...] Read more.
Breast cancer (BC) is one of the most common cancers in women and is a major cause of female cancer-related deaths. BC is a multifactorial disease caused by the dysregulation of many genes, raising the need to find novel drugs that function by targeting several signaling pathways. The antitumoral drug thymoquinone (TQ), found in black seed oil, has multitargeting properties against several signaling pathways. This study evaluated the inhibitory effects of TQ on the MCF7 and T47D human breast cancer cell lines and its antitumor activity against BC induced by a single oral dose (65 mg/kg) of 7,12-dimethylbenzanthracene (DMBA) in female rats. The therapeutic activity was evaluated in DMBA-treated rats who received oral TQ (50 mg/kg) three times weekly. TQ-treated MCF7 and T47D cells showed concentration-dependent inhibition of cell proliferation and induction of apoptosis. TQ also decreased the expression of DNA methyltransferase 1 (DNMT1) in both cancer cell types. In DMBA-treated animals, TQ inhibited the number of liver and kidney metastases. These effects were associated with a reduction in DNMT1 mRNA expression. These results indicate that TQ has protective effects against breast carcinogens through epigenetic mechanisms involving DNMT1 inhibition. Full article
(This article belongs to the Special Issue Chemical and Biological Research on Bioactive Natural Products)
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