Synthesis, Biotransformation and Neuronal Effects of Heterocyclic Compounds

Dear Colleagues,

Heterocyclic systems are an important class of compounds in rational drug design aiming to discover a new, safe and selective way to treat neurological conditions that could provide a breakthrough for physicians, patients and the pharmaceutical industry. Current trends in medicinal chemistry are directed toward the search for new derivatives with improved pharmacological potential based on the five- and six-term heterocyclic ring-based compounds. The introduction, substitution, addition, removal and/or fusion of different functional groups in a heterocyclic core is a potent instrument for the comprehension of the neurological characterization of new compounds. The identification of molecules with interesting multi-target profiles, the screening of old drugs that are proved effective through the interaction with new important targets and the preparation of natural-based synthetic molecules to become potential candidates to protect neurons against degeneration is addressed in many research areas attempting to obtain better therapeutic action and fewer side effects. In addition, the safety profile of biologically active substances is closely dependent on the creation of appropriate highly informative analytical methods for control and standardization. Thus, the research on biotransformation, including the prediction of ADMET properties, is directly related to the achievement of improved pharmacokinetic, pharmacological, and toxicological profiles of these molecules.

Prof. Dr. Magdalena Kondeva-Burdina
Dr. Maya Georgieva
Guest Editors

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• synthesis
• in silico drug design
• biotransformation
• neurotoxicity and neuroprotection
• in vitro and in vivo assay
• heterocycles
• drug analysis
• ADMET