MRI Contrast Agents: Current Challenges and New Progresses
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 5620
Special Issue Editor
Interests: biomedical NMR and molecular imaging; development and evaluation of contrast agents for MRI and multimodal imaging; nanosystems for theranostics and multimodal imaging
Special Issue Information
Dear Colleagues,
Magnetic resonance imaging (MRI) is one of the most important clinical imaging modalities, and a large percentage of MRI clinical exams use a gadolinium (Gd) containing contrast agent (CA) to enhance image contrast. The spectacular success of Gd-based contrast agents (GBCAs) stimulated research on various lanthanide chelates for MR applications. This Special Issue of Molecules, entitled “MRI Contrast Agents: Current Challenges and New Frontiers”, aims at including original manuscripts, technical reports, and reviews reporting innovative research on all aspects of MRI CAs as powerful tools in medical diagnostics. These include, but are not limited to, smart/responsive/angiographic Gd3+ and transition metal complexes, such as Fe and Mn at different oxidation states, as well as soft nanomaterials, such as metal labelled micelles, liposomes, dendrimers, carbon-based nanotubes, biopolymers and other aggregates, hard nanomaterials, including iron oxides, ferrites, metal-organic frameworks and Ln3+ containing nanoparticles, and nanocomposites. Nanoplatforms for MRI based multimodal and/or theranostic applications are also included, as well as computer-based modelling of MRI contrast agents and experimental characterization of the systems, working on the basis of nuclear spin relaxation (T1, T2, T2*), chemical exchange saturation transfer (CEST) or PARASHIFT mechanisms. Due to recent reports on adverse effects related to in vivo Gd-release and deposition, focus on the improvement of in vivo stability as well as the exploration of transition metal-based agents and metal-free agents, such as 19F-based MRI agents, organic free radicals, and hyperpolarized probes is an important goal.
Prof. Dr. Carlos Geraldes
Guest Editor
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Keywords
- magnetic resonance imaging (MRI)
- contrast agents
- Gd and transition metal complexes
- physicochemical parameters of complexes
- responsive/targeted agents
- CEST/paraCEST/ PARASHIFT probes
- superparamagnetic nanoparticles
- lanthanide-based nanoparticles
- MRI-based multimodal and theranostic nanoparticles