Fluorescence Probes as Disease Molecular Diagnosis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 7458
Special Issue Editors
Interests: nucleic acid analysis; single-cell analysis; RNA imaging; fluorescence imaging; single-molecule imaging
Interests: fluorescence imaging; small-molecule fluorescent probe; nanoprobe; accurate diagnosis; organic synthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With the progress of human genome research, the understanding of diseases’ occurrence and development has also deepened, from their morphological appearance to the molecular level. The revelation of molecular characteristics not only helps to improve the accuracy of diagnosis but, more importantly, information on the molecular markers related to disease prognosis helps doctors to take timely and effective clinical measures. Molecular diagnosis provides a powerful tool for the accurate diagnosis and treatment of clinical diseases, which can be used to evaluate patient risk, provide early diagnosis, monitoring and early warning, improve the therapeutic effect, and slow down and even prevent the occurrence of diseases.
Molecular targeted fluorescent probes can be used for the detection of disease biomarkers and provide reliable tools for the molecular diagnosis of diseases due to their high sensitivity, simple operation, low detection limit, fast response, excellent spatial and temporal resolution and non-destructive in situ imaging. A wide range of fluorescence probe-based techniques have been developed for the molecule diagnosis of biomarkers such as RNA, DNA, mutations, including near-infrared fluorescence probes, fluorescence resonance energy transfer (FRET) probes, nucleic acid amplification technology, multi-target joint detection, cell/pathological tissue imaging, in vivo imaging etc. These technologies assist in precise diagnosis and deepen our understanding of disease mechanisms.
This Special Issue aims to collect basic and applied research focusing on fluorescence probes for molecular diagnosis using nucleic acid technology, nanotechnology, organic synthesis, click chemistry, bioconjugate chemistry or other fundamental approaches. We welcome the submission of both original research articles and review articles on the provision of novel tools for fluorescent molecular diagnosis.
Dr. Xiaojun Ren
Prof. Dr. Dongdong Su
Guest Editors
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Keywords
- fluorescence probes
- biomarker
- fluorescence imaging
- molecular diagnosis
- nucleic acid amplification
- prognosis
- nanotechnology
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