molecules-logo

Journal Browser

Journal Browser

Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 455

Special Issue Editors


E-Mail Website
Guest Editor
Department of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, 8 Skromna Street, 20-704 Lublin, Poland
Interests: analytical chemistry; chromatography; extraction; phytochemistry; food technology; essential oils; aromas; herbal drug development; antioxidants; dietary supplements; special fats technology; quality and food safety; food contaminations
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, PL-20-093 Lublin, Poland
Interests: natural product chemistry; antioxidants; analytical chemistry; bioactivity; phytochemicals; extraction

Special Issue Information

Dear Colleagues,

“Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities” is dedicated to unlocking the potential of compounds found in nature. This topic delves into efficient methods for extracting these valuable substances from various natural sources, the precise techniques for isolating them, and the comprehensive strategies for characterizing their properties.

Researchers in this field employ a wide array of tools and methodologies to discover, isolate, and understand the diverse compounds present in plants, microbes, marine organisms, and other natural reservoirs. Secondary plant metabolites are of particular interest. These compounds often possess bioactive properties, making them invaluable for applications in medicine, agriculture, and industry.

The study of natural products extends to examining their chemical structures, assessing biological activities (including antimicrobial, antioxidant, and anticancer properties), elucidating their modes of action, and assessing their potential for drug development, functional foods, and sustainable materials. Moreover, the topic explores sustainable practices that align with environmental conservation and the responsible utilization of nature's wealth.

As an interdisciplinary topic, “Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities” bridges chemistry, biology, pharmacology, and environmental science, fostering collaboration among experts from various domains. It also underscores the importance of preserving biodiversity and exploring new frontiers in natural product research.

Prof. Dr. Radosław Kowalski
Dr. Tomasz Baj
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • secondary metabolites
  • analytical techniques application
  • extraction and separation
  • chemical composition
  • phytochemistry
  • isolation and structure elucidation
  • secondary metabolites
  • antimicrobial activity
  • antioxidant activity
  • anticancer activity

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 1938 KiB  
Article
New Pyranone Derivatives and Sesquiterpenoid Isolated from the Endophytic Fungus Xylaria sp. Z184
by Yan Zhang, Yang Jin, Wensi Yan, Peishan Gu, Ziqian Zeng, Ziying Li, Guangtao Zhang, Mi Wei and Yongbo Xue
Molecules 2024, 29(8), 1728; https://doi.org/10.3390/molecules29081728 - 11 Apr 2024
Viewed by 319
Abstract
The fungus Xylaria sp. Z184, harvested from the leaves of Fallopia convolvulus (L.) Á. Löve, has been isolated for the first time. Chemical investigation on the methanol extract of the culture broth of the titles strain led to the discovery of three new [...] Read more.
The fungus Xylaria sp. Z184, harvested from the leaves of Fallopia convolvulus (L.) Á. Löve, has been isolated for the first time. Chemical investigation on the methanol extract of the culture broth of the titles strain led to the discovery of three new pyranone derivatives, called fallopiaxylaresters A–C (13), and a new bisabolane-type sesquiterpenoid, named fallopiaxylarol A (4), along with the first complete set of spectroscopic data for the previously reported pestalotiopyrone M (5). Known pyranone derivatives (611), sesquiterpenoids (1214), isocoumarin derivatives (1517), and an aromatic allenic ether (18) were also co-isolated in this study. All new structures were elucidated by the interpretation of HRESIMS, 1D, 2D NMR spectroscopy, and quantum chemical computation approach. The in vitro antimicrobial, anti-inflammatory, and α-glucosidase-inhibitory activities of the selected compounds and the crude extract were evaluated. The extract was shown to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells, with an inhibition rate of 77.28 ± 0.82% at a concentration of 50 μg/mL. The compounds 5, 7, and 8 displayed weak antibacterial activity against Staphylococcus areus subsp. aureus at a concentration of 100 μM. Full article
Show Figures

Graphical abstract

Back to TopTop