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Advanced Functional Nanomaterials in Medicine and Health Care

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1374

Special Issue Editors


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Guest Editor
NanoBioMedical Centre, Adam Mickiewicz University, 61-614 Poznań, Poland
Interests: synthesis; biofunctionalization and physico-chemical properties of nanomaterials and their application in biomedicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, 61-614 Poznan, Poland
Interests: bioimaging using magnetic resonance imaging; NMR spectroscopy; molecular dynamics in biological systems; contrast agents for MRI and FMT imaging

E-Mail Website
Guest Editor
NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Wszechnicy Piastowskiej 3, PL 61614 Poznan, Poland
Interests: synthesis and functionalization of metal nanoparticles; nanomaterials in membrane processes; drug delivery systems, nanomaterials in biomedical fields

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Guest Editor
NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, 61-614 Poznań, Poland
Interests: targeted delivery of quantum dots to cancer cells; cellular internalization of nanoparticles; testing the bactericidal/bacteriostatic properties of nanomaterials; nanotoxicity analysis; cytogenetic and physical mapping of genes; gene and protein expression analysis

Special Issue Information

Dear Colleagues,

Technological innovations that cover virtually every branch of medicine and health care are necessary to provide safe, precise, and thus more efficient disease prevention and treatment, as well as improved quality of life for patients. This progress has also manifested in recent advancements in functional nanomaterials and nanotechnologies for diagnostics, therapeutics, and drug delivery systems. These advancements have potential clinical applications which show increasingly promising outcomes. However, there is still much work to be achieved in this area. In this Special Issue, we would like to highlight the growing interest in this field of advanced functional nanomaterials, which is currently becoming more and more established. Therefore, submissions covering all aspects of novel nanomaterials and nanotechnologies and their applications throughout the medicinal and healthcare field are welcome. These aspects include, i.e., novel approaches for the design and synthesis of nanomaterials and their bio-/functionalization, novel nanomedicine-based treatment strategies, including targeting ability, biocompatibility and biosafety issues, pre- and clinical applications, implementation of nanomaterials in medical and health care devices, theory and modeling of nanomaterial and nanodevices, advances in characterization techniques of nanomaterials for biomedical applications.

This Special Issue is also suited for participants of the NanoTech Poland 2024 conference, which will be held on 5–7 June 2024 in Poznań, Poland (https://nanotechpoland.amu.edu.pl/), whose contributions fall into the topical section B: Nanobiomedicine.

Dr. Dorota Katarzyna Flak
Dr. Tomasz Zalewski
Dr. Marta Joanna Woźniak-Budych
Dr. Łucja Przysiecka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug and nucleic acid delivery
  • imaging/contrast agent delivery
  • theranostic nanoparticles
  • nanovaccines
  • personalised medicine
  • targeted therapy
  • nanobiotechnology
  • nanodevice
  • regenerative medicine
  • biosafety/biocompatibility of nanomaterials
  • stability of nanomaterials in biological fluids
  • nanotoxicology
  • pharmacokinetics and pharmacodynamics
  • nanoinformatics and nanomodelling

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Published Papers (1 paper)

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Research

17 pages, 4439 KiB  
Article
The Use of Organoclays as Excipient for Metformin Delivery: Experimental and Computational Study
by Sondes Omrani, Safa Gamoudi, César Viseras, Younes Moussaoui and C. Ignacio Sainz-Díaz
Molecules 2024, 29(19), 4612; https://doi.org/10.3390/molecules29194612 - 28 Sep 2024
Viewed by 490
Abstract
This work combines experimental and computational modeling studies for the preparation of a composite of metformin and an organoclay, examining the advantages of a Tunisian clay used for drug delivery applications. The clay mineral studied is a montmorillonite-like smectite (Sm-Na), and the organoclay [...] Read more.
This work combines experimental and computational modeling studies for the preparation of a composite of metformin and an organoclay, examining the advantages of a Tunisian clay used for drug delivery applications. The clay mineral studied is a montmorillonite-like smectite (Sm-Na), and the organoclay derivative (HDTMA-Sm) was used as a drug carrier for metformin hydrochloride (MET). In order to assess the MET loading into the clays, these materials were characterized by means of cation exchange capacity assessment, specific surface area measurement, and with the techniques of X-ray diffraction (XRD), differential scanning calorimetry, X-ray fluorescence spectroscopy, and Fourier-transformed infrared spectroscopy. Computational molecular modeling studies showed the surface adsorption process, identifying the clay–drug interactions through hydrogen bonds, and assessing electrostatic interactions for the hybrid MET/Sm-Na and hydrophobic interactions and cation exchange for the hybrid MET/HDTMA-Sm. The results show that the clays (Sm-Na and HDTMA-Sm) are capable of adsorbing MET, reaching a maximum load of 12.42 and 21.97 %, respectively. The adsorption isotherms were fitted by the Freundlich model, indicating heterogeneous adsorption of the studied adsorbate–adsorbent system, and they followed pseudo-second-order kinetics. The calculations of ΔGº indicate the spontaneous and reversible nature of the adsorption. The calculation of ΔH° indicates physical adsorption for the purified clay (Sm-Na) and chemical adsorption for the modified clay (HDTMA-Sm). The release of intercalated MET was studied in media simulating gastric and intestinal fluids, revealing that the purified clay (Sm-Na) and the modified organoclay (HDTMA-Sm) can be used as carriers in controlled drug delivery in future clinical applications. The molecular modeling studies confirmed the experimental phenomena, showing that the main adsorption mechanism is the cation exchange process between proton and MET cations into the interlayer space. Full article
(This article belongs to the Special Issue Advanced Functional Nanomaterials in Medicine and Health Care)
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