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Targeted Functional Probe: Current Research Trends and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1550

Special Issue Editors


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Guest Editor
School of Life Sciences, Central China Normal University, Wuhan 430079, China
Interests: targeted functional probe; luminescent materials; tumor theranostics; peptide chemistry; analyte-responsive imaging; targeted therapy

E-Mail Website
Guest Editor
College of Physical Science and Technology, Central China Normal University, Wuhan 430079, China
Interests: computer-aided drug design; biomolecular interactions; molecular dynamics simulation; biophysics; bioinformatics

Special Issue Information

Dear Colleagues,

Targeted functional probes have been deemed as essential for accurate diagnostic imaging. These probes can be conjugated with different types of ligands, for example organic molecules, peptides, and proteins, to target specific biological sites. During the last few decades, many targeted probes based on small molecules, polymers, and nanomaterials have been synthesized to detect different types of analytes with outstanding performance.

The development of targeted functional probes is promising for the study of diseases. They can selectively visualize tumor cells and invisible organelles. With the use of different real-time imaging techniques, such as fluorescence imaging (FI), magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), scientists can directly measure the signals provided by the probe to explore the location and function of different targets, and even monitor the changes in the condition and disorder of the target.

The purpose of this Special Issue is to collect the latest advances in the design and development of targeted functional probes. We welcome all original research works, including research articles, communications, and reviews on new targeting strategies or sensing mechanisms, the design of multi-functional targeted probes, and the widespread application of targeted functional probes.

Dr. Lijun Jiang
Dr. Yunhui Peng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new design strategies
  • new sensing mechanisms
  • computer-aided design
  • selective targeting among multiple analytes
  • multi-functionality
  • targeted imaging/therapy against cancer

Published Papers (1 paper)

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Review

23 pages, 6315 KiB  
Review
Recent Advances in Organometallic NIR Iridium(III) Complexes for Detection and Therapy
by Shaozhen Jing, Xiaolei Wu, Dou Niu, Jing Wang, Chung-Hang Leung and Wanhe Wang
Molecules 2024, 29(1), 256; https://doi.org/10.3390/molecules29010256 - 03 Jan 2024
Viewed by 1252
Abstract
Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, and high quantum yields. In recent years, much effort has been devoted to develop [...] Read more.
Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, and high quantum yields. In recent years, much effort has been devoted to develop novel near-infrared (NIR) iridium(III) complexes to improve signal-to-noise ratio and enhance tissue penetration. In this review, we summarize different classes of organometallic NIR iridium(III) complexes for detection and therapy, including cyclometalated ligand-enabled NIR iridium(III) complexes and NIR-dye-conjugated iridium(III) complexes. Moreover, the prospects and challenges for organometallic NIR iridium(III) complexes for targeted detection and therapy are discussed. Full article
(This article belongs to the Special Issue Targeted Functional Probe: Current Research Trends and Applications)
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