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Hydrogels: Preparation, Characterization, and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 758

Special Issue Editors


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Guest Editor
Material Science and Engineering School, Sun Yat-sen (Zhongshan) University, Guangzhou 510275, China
Interests: hydrogels; preparation; characterization; applications
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
College of Chemistry, Sichuan University, Chengdu 610064, China
Interests: hydrogels; preparation; characterization; applications

Special Issue Information

Dear Colleagues,

Hydrogels with three-dimensional (3D) network structures are commonly prepared through the physical, chemical, and enzymatic cross-linking of hydrophilic compounds. These hydrogels, which are swell in water while retaining a significant amount of it within their 3D structures, have widespread applications in the biomedical field, environmental protection, food engineering, wearable devices, etc. In recent years, substantial progress has been made in fabricating diverse functional hydrogel materials by designing functional monomers, dynamic cross-linking networks, and topological architectures. Consequently, in this Special Issue, we aim to invite original research and review articles on advanced functional hydrogels, addressing the latest advancements in the design, preparation, characterization, and application of hydrogels across various domains, including food, the environment, energy, medicine, biology, and smart wearable systems.

Prof. Dr. Li-Ming Zhang
Prof. Dr. Fei Song
Guest Editors

Manuscript Submission Information

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Keywords

  • hydrogels
  • preparations
  • characterization
  • applications

Published Papers (1 paper)

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Research

18 pages, 7989 KiB  
Article
Injectable Hydrogels Based on Hyaluronic Acid and Gelatin Combined with Salvianolic Acid B and Vascular Endothelial Growth Factor for Treatment of Traumatic Brain Injury in Mice
by Guoying Zhou, Yajie Cao, Yujia Yan, Haibo Xu, Xiao Zhang, Tingzi Yan and Haitong Wan
Molecules 2024, 29(8), 1705; https://doi.org/10.3390/molecules29081705 - 10 Apr 2024
Viewed by 532
Abstract
Traumatic brain injury (TBI) leads to structural damage in the brain, and is one of the major causes of disability and death in the world. Herein, we developed a composite injectable hydrogel (HA/Gel) composed of hyaluronic acid (HA) and gelatin (Gel), loaded with [...] Read more.
Traumatic brain injury (TBI) leads to structural damage in the brain, and is one of the major causes of disability and death in the world. Herein, we developed a composite injectable hydrogel (HA/Gel) composed of hyaluronic acid (HA) and gelatin (Gel), loaded with vascular endothelial growth factor (VEGF) and salvianolic acid B (SAB) for treatment of TBI. The HA/Gel hydrogels were formed by the coupling of phenol-rich tyramine-modified HA (HA-TA) and tyramine-modified Gel (Gel-TA) catalyzed by horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2). SEM results showed that HA/Gel hydrogel had a porous structure. Rheological test results showed that the hydrogel possessed appropriate rheological properties, and UV spectrophotometry results showed that the hydrogel exhibited excellent SAB release performance. The results of LIVE/DEAD staining, CCK-8 and Phalloidin/DAPI fluorescence staining showed that the HA/Gel hydrogel possessed good cell biocompatibility. Moreover, the hydrogels loaded with SAB and VEGF (HA/Gel/SAB/VEGF) could effectively promote the proliferation of bone marrow mesenchymal stem cells (BMSCs). In addition, the results of H&E staining, CD31 and α-SMA immunofluorescence staining showed that the HA/Gel/SAB/VEGF hydrogel possessed good in vivo biocompatibility and pro-angiogenic ability. Furthermore, immunohistochemical results showed that the injection of HA/Gel/SAB/VEGF hydrogel to the injury site could effectively reduce the volume of defective tissues in traumatic brain injured mice. Our results suggest that the injection of HA/Gel hydrogel loaded with SAB and VEGF might provide a new approach for therapeutic brain tissue repair after traumatic brain injury. Full article
(This article belongs to the Special Issue Hydrogels: Preparation, Characterization, and Applications)
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