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Novel Design and Synthesis of Anticancer Agents (Second Edition)

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1291

Special Issue Editor


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Guest Editor
Department of Organic Chemistry, Medical University of Silesia, Katowice, Poland
Interests: organic chemistry; medicinal chemistry; synthesis of organic compounds; spectroscopy analysis; lipophilicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neoplastic diseases and cardiovascular diseases are the leading causes of premature death. Despite the significant progress made over the last few decades on the molecular basis of the carcinogenesis process as well as diagnostic and prophylactic processes, the treatment currently used for neoplastic diseases is still not very specific or effective. We are currently facing numerous challenges related to the search for progress in cancer chemotherapy.

The design and synthesis of more effective and more selective novel anticancer drug candidates with promising activity and minimal side effects still remains a problem.

Currently, the search for new anticancer therapies is focused, inter alia, on the search for improved pharmaceutical forms (drug forms) and new analogues of the currently used anticancer drugs, on the study of the antitumor activity of drugs currently used for other indications, and on the study of new chemical compounds of natural or synthetic origin with the anticancer activities.

In this Special Issue, we focus on research related to the design and synthesis of new substances with potential anticancer activity, as well as the study of the mechanisms of this action. I cordially invite researchers working in this field to contribute original research articles and review articles.

Dr. Małgorzata Jeleń
Guest Editor

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Keywords

  • synthesis
  • anti-proliferative activity
  • anticancer activity
  • cancer cell lines
  • mechanism of anticancer action
  • drug discovery
  • drug design

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Published Papers (1 paper)

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Review

24 pages, 8275 KiB  
Review
Recent Development of Fluoroquinolone Derivatives as Anticancer Agents
by Justyna Nowakowska, Dominika Radomska, Robert Czarnomysy and Krzysztof Marciniec
Molecules 2024, 29(15), 3538; https://doi.org/10.3390/molecules29153538 - 27 Jul 2024
Viewed by 966
Abstract
Cancer is the second leading cause of death in the world following cardiovascular disease. Its treatment, including radiation therapy and surgical removal of the tumour, is based on pharmacotherapy, which prompts a constant search for new and more effective drugs. There are high [...] Read more.
Cancer is the second leading cause of death in the world following cardiovascular disease. Its treatment, including radiation therapy and surgical removal of the tumour, is based on pharmacotherapy, which prompts a constant search for new and more effective drugs. There are high costs associated with designing, synthesising, and marketing new substances. Drug repositioning is an attractive solution. Fluoroquinolones make up a group of synthetic antibiotics with a broad spectrum of activity in bacterial diseases. Moreover, those compounds are of particular interest to researchers as a result of reports of their antiproliferative effects on the cells of the most lethal cancers. This article presents the current progress in the development of new fluoroquinolone derivatives with potential anticancer and cytotoxic activity, as well as structure–activity relationships, along with possible directions for further development. Full article
(This article belongs to the Special Issue Novel Design and Synthesis of Anticancer Agents (Second Edition))
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