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Cutting-Edge Isolation Characterization and Pharmaceutical Formulation of Natural Products and Their Derivatives

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2058

Special Issue Editors


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Guest Editor
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Interests: drug development and delivery; solid dispersion; drug formulation

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Guest Editor
National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Interests: natural products; isolation; NMR; analysis; cannabis

E-Mail Website
Guest Editor
National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Interests: natural products; cannabis; cannabinoids chemistry; pharmacology; toxicology and pharmaceutics; chemical analysis

Special Issue Information

Dear Colleagues,

Natural products and natural product derivatives have been a source of inspiration and innovation in various fields, such as from medicine to cosmetics, for centuries. They offer a vast and diverse array of chemical compounds with unique properties and potential applications. In recent years, the focus on natural products has intensified, driven by a growing interest in sustainable and environmentally friendly solutions as well as the recognition of their therapeutic and commercial value.

This Special Issue, titled “Cutting-Edge Isolation, Characterization, and Pharmaceutical Formulation of Natural Products,” aims to showcase the latest advancements in the field. It provides a platform for researchers, scientists, and experts to present their cutting-edge discoveries and insights, with a specific focus on the isolation, chemical and biological characterization, and pharmaceutical formulation of natural products.

Potential topics include, but are not limited to

  1. Innovative techniques for the isolation of natural compounds;
  2. Advances in the chemical analysis and structural elucidation of natural products;
  3. Biological activities and pharmacological studies of natural products and natural products’ derivatives;
  4. Sustainable and green chemistry approaches to natural product research;
  5. Formulation and development of natural product-based pharmaceuticals;
  6. Total synthesis of complex natural products;
  7. Quality control and standardization of natural product extracts;
  8. Potential practical applications in different fields (e.g., agriculture, food packaging, medicine, and cosmetics).

Through this collection of papers, we hope to foster a deeper understanding of natural products, their potential benefits, and their applications across various industries. Researchers are encouraged to contribute their work in these topics and their related areas to advance our knowledge and contribute to the sustainable utilization of natural resources.

Dr. Eman Ashour
Dr. Mohamed M. Radwan
Prof. Dr. Mahmoud A. ElSohly
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • natural product derivatives
  • isolation techniques
  • chemical and/or biological characterization
  • pharmaceutical formulation
  • drug discovery
  • bioprospecting
  • sustainable chemistry

Published Papers (1 paper)

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Review

31 pages, 2126 KiB  
Review
Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol
by Maged S. Abdel-Kader, Mohamed M. Radwan, Ahmed M. Metwaly, Ibrahim H. Eissa, Arno Hazekamp and Mahmoud A. ElSohly
Molecules 2024, 29(6), 1249; https://doi.org/10.3390/molecules29061249 - 11 Mar 2024
Viewed by 1870
Abstract
Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has moved and flourished in the Western nations in more recent centuries. [...] Read more.
Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has moved and flourished in the Western nations in more recent centuries. C. sativa is the source of psychoactive cannabinoids that are consumed as recreational drugs worldwide. The C21 aromatic hydrocarbons are restricted in their natural occurrence to cannabis (with a few exceptions). Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive component in cannabis, with many pharmacological effects and various approved medical applications. However, a wide range of side effects are associated with the use of Δ9-THC, limiting its medical use. In 1966, another psychoactive cannabinoid, Delta-8-tetrahydrocannabinol (Δ8-THC) was isolated from marijuana grown in Maryland but in very low yield. Δ8-THC is gaining increased popularity due to its better stability and easier synthetic manufacturing procedures compared to Δ9-THC. The passing of the U.S. Farm Bill in 2018 led to an increase in the sale of Δ8-THC in the United States. The marketed products contain Δ8-THC from synthetic sources. In this review, methods of extraction, purification, and structure elucidation of Δ8-THC will be presented. The issue of whether Δ8-THC is a natural compound or an artifact will be discussed, and the different strategies for its chemical synthesis will be presented. Δ8-THC of synthetic origin is expected to contain some impurities due to residual amounts of starting materials and reagents, as well as side products of the reactions. The various methods of analysis and detection of impurities present in the marketed products will be discussed. The pharmacological effects of Δ8-THC, including its interaction with CB1 and CB2 cannabinoid receptors in comparison with Δ9-THC, will be reviewed. Full article
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