Molecules against Alzheimer
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (29 February 2016) | Viewed by 126872
Special Issue Editors
Interests: hybrid compounds; multifunctional cholinesterase inhibitors; cannabinoid and other GPCR ligands; natural products
Special Issues, Collections and Topics in MDPI journals
Interests: multitarget anti-Alzheimer agents; hybrid compounds; cholinesterase inhibitors; amyloid anti-aggregating compounds; BACE-1 inhibitors; antiprotozoan compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is a devastating disease with regard to its ever-increasing global prevalence, as well to its effects on individual patients and caregivers. Currently, it can only be treated with acetylcholinesterase inhibitors or an NMDA antagonist, but these drugs only afford a symptomatic relief for a limited time. This very modest outcome of drug development is surprising due to the many research efforts and breakthroughs in AD biochemistry and pathophysiology. Obviously, AD’s highly complex interaction of multifactorial neurodegenerative disease processes challenges medicinal chemists and drug developers.
This Special Issue aims to highlight recent efforts on the early medicinal chemistry stage of anti-Alzheimer drug development, and wants to put a special focus on innovative applications of multifunctional and hybrid molecules, as well as the use of natural products for lead identification. In this Special Issue we intend to present the most interesting examples and applications of the following topics: the design and synthesis of multipotent lead structures, the chemical basis of the development of diagnostic imaging agents, the application of natural products and their derivatives for development of neuroprotectants, rational design and related innovative approaches to AD drugs.
We welcome original articles and short communications as well as a limited number of review articles on novel methods and approaches for AD drug development. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Prof. Dr. Michael Decker
Prof. Dr. Diego Muñoz-Torrero
Guest Editor
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- drug discovery
- rational design
- hybrid molecules
- multi-target-directed molecules
- polypharmacology
- biomarkers, imaging agents
- neuroprotectants
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