Innovative Computational and Experimental Approaches for Tackling Neurodegenerative Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 6515
Special Issue Editors
Interests: computational approaches; drug discovery; drug design; molecular modeling; computational chemistry; virtual screening
Special Issues, Collections and Topics in MDPI journals
Interests: computational approaches; drug discovery; drug design; molecular modeling; computational chemistry; virtual screening
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative disorders represent an extremely diverse group of pathological conditions caused by the loss of function of cells located in the central and/or peripheral nervous systems. Several neurodegenerative diseases have been discovered, most of them characterized by a progressive decline of cognitive functions that can result in significant deficits of personality and memory. The identification of effective therapeutic approaches for the treatment of these diseases is of the utmost importance. This is especially true considering that they overall affect more than 5% of worldwide population, with a growing trend owing to aging. Regretfully, effective therapeutic treatments for preventing or solving most of these disorders is missing. Significant drug development efforts have been addressed via computational and experimental methods in the search for novel therapeutic approaches for tackling neurodegenerative diseases. This research has also been supported by the recent increasing level of understanding of the physiopathology of such disorders. On these premises, this Special Issue aims to focus on:
- The application of computational and experimental approaches to facilitate the understanding of the mechanisms involved in neurodegenerative disorders at the molecular level;
- The discovery and characterization of novel therapeutic targets for tackling neurodegenerative diseases;
- The application of innovative experimental approaches, including omics sciences and network pharmacology in research related to neurodegenerative disorders;
- The application of computational approaches such as bioinformatics, chemoinformatics, artificial intelligence, data-driven techniques and molecular modelling in neurodegenerative disease research;
- The combined application of experimental and computational methods in neurodegenerative disease research;
- The application of innovative approaches such as drug repurposing and polypharmacology in neurodegenerative disease research.
Original research articles, short communications, perspectives and insightful reviews providing fruitful considerations and discussions on research related to neurodegenerative diseases are welcome in this Special Issue.
Dr. Luca Pinzi
Prof. Dr. Giulio Rastelli
Guest Editors
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Keywords
- neurodegenerative diseases
- Alzheimer’s disease
- Parkinson’s disease
- disordered proteins
- molecular modelling
- chemoinformatics
- artificial intelligence
- experimental techniques
- polypharmacology
- drug repurposing
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