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Collection of Scientific Papers by Outstanding Scientists in the Field of Bioorganic Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 468

Special Issue Editors


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Guest Editor
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany
Interests: bioorganic chemistry; catalytic sensor/effector agents; epistemology; intracellular diagnostics; nanotechnology; natural products; reactive sulfur and selenium species; redox regulation via the cellular thiolstat
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to submit manuscripts to this Special Issue entitled “Collection of Scientific Papers by Outstanding Scientists in the Field of Bioorganic Chemistry”. The main purpose of this Special Issue is to publish selected original scientific papers written by outstanding scientists describing research carried out on bioorganic chemistry using the latest technological achievements. Topics of interest include but are not limited to the following:

  • Enzyme inhibitors;
  • Enzyme immobilization and controlled enzyme immobilization;
  • Biocatalysis (ribozymes and catalytic antibodies);
  • Biosynthesis;
  • Immunochemical techniques;
  • Membrane chemistry;
  • Protein and small biomolecules;
  • Peptides chemistry;
  • Biopolymers and artificial supramolecular assemblies;
  • Molecular recognition of nucleic acids;
  • Bioactive lipids;
  • Non-natural amino acids;
  • Mass spectrometry studies on biomolecules;
  • Bioactive peptides and proteins;
  • Biological signaling.

We kindly invite and encourage all research groups covering various bioorganic chemistry areas to submit contributions to this Special Issue.

Prof. Dr. Claus Jacob
Prof. Dr. Riccardo Spaccini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioorganic chemistry
  • enzyme inhibitors
  • biosynthesis
  • immunochemical techniques
  • peptides chemistry

Published Papers (1 paper)

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Review

24 pages, 6624 KiB  
Review
Bond Formation at C8 in the Nucleoside and Nucleotide Purine Scaffold: An Informative Selection
by Kjell Undheim
Molecules 2024, 29(8), 1815; https://doi.org/10.3390/molecules29081815 - 17 Apr 2024
Viewed by 312
Abstract
This paper presents methods for the introduction and exchange of substituents in a nucleobase and its nucleosides and nucleotides with emphasis on the C8-position in the purine skeleton. The nucleobase is open for electrophilic and nucleophilic chemistry. The nucleophilic chemistry consists mainly of [...] Read more.
This paper presents methods for the introduction and exchange of substituents in a nucleobase and its nucleosides and nucleotides with emphasis on the C8-position in the purine skeleton. The nucleobase is open for electrophilic and nucleophilic chemistry. The nucleophilic chemistry consists mainly of displacement reactions when the C8-substituent is a good leaving group such as a halogen atom. The heteroatom in amines, sulfides, or oxides is a good nucleophile. Halides are good reaction partners. Metal-promoted cross-coupling reactions are important for carbylations. Direct oxidative metalation reactions using sterically hindered metal amides offer chemo- and regio-selectivity besides functional tolerance and simplicity. The carbon site is highly nucleophilic after metalation and adds electrophiles resulting in chemical bond formation. Conditions for metal-assisted reactions are described for nucleobases and their glycosides. Full article
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