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Novel Green Catalysts and Applications of Organocatalysis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2515

Special Issue Editor

Department of Chemistry, School of Science, Tianjin University, Tianjin, China
Interests: organocatalysis; green reactions; heterogeneous catalysis; cooperative catalysis; organic polymer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Small organic molecules have been used as catalysts in organic and inorganic transformations for a long time. Especially since proline and imidazolidinone were employed to efficiently catalyze asymmetric reactions as the milestones, organocatalysts have been given much more attention. With even better performance than enzymes, organocatalysts may overcome some of the drawbacks of enzymes and metal catalysts, which means that they are sometimes more practical in the chemical industry.

This Special Issue is established to collect new developments on chemical transformations via organocatalysis. This involves but is not limited to research work and reviews on small organic molecule catalysts and their immobilized heterogeneous counterparts. The manuscripts could also be related to transition metal-free organic materials with catalytic activity, such as organic macromolecules/polymers, carbon-based materials, covalent organic frameworks (COFs), and other organic nanomaterials. Moreover, comparisons of organocatalysts with metal and/or enzyme catalysts are welcome in this issue.

Dr. Ning Ma
Guest Editor

Manuscript Submission Information

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Keywords

  • organocatalysis
  • green reactions
  • asymmetric synthesis
  • heterogeneous catalysis
  • transition metal-free catalysts
  • catalytically active organic materials

Published Papers (2 papers)

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Research

12 pages, 3168 KiB  
Article
Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach
by Yuliang Hu, Jinping Bao, Dongyu Tang, Shushan Gao, Fei Wang, Zhongtao Ding and Chengsen Cui
Molecules 2024, 29(6), 1328; https://doi.org/10.3390/molecules29061328 - 16 Mar 2024
Viewed by 869
Abstract
(R)-Homobenzylic amines are key structural motifs present in (R)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective [...] Read more.
(R)-Homobenzylic amines are key structural motifs present in (R)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective biocatalytic reductive amination as the key step. The imine reductase IR36-M5 mutant showed high conversion (97%) and stereoselectivity (97%) toward the phenylacetone and propargyl amine substrates, offering valuable biocatalysts for synthesizing alkylated homobenzylic amines. Full article
(This article belongs to the Special Issue Novel Green Catalysts and Applications of Organocatalysis)
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12 pages, 3095 KiB  
Article
Visible Light-Mediated Organoboron-Catalyzed Metal-Free Synthesis of Silanols from Silanes
by Jinbo Yang, Xiangxue Cao, Lanfeng Wei, Jianshu Zhang, Jinli Zhang, Ping Liu, Liang Xu and Pengfei Li
Molecules 2023, 28(10), 4082; https://doi.org/10.3390/molecules28104082 - 13 May 2023
Cited by 3 | Viewed by 1350
Abstract
Herein, a four-coordinated organoboron compound, aminoquinoline diarylboron (AQDAB), is utilized as the photocatalyst in the oxidation of silane to silanol. This strategy effectively oxidizes Si–H bonds, affording Si–O bonds. Generally, the corresponding silanols can be obtained in moderate to good yields at room [...] Read more.
Herein, a four-coordinated organoboron compound, aminoquinoline diarylboron (AQDAB), is utilized as the photocatalyst in the oxidation of silane to silanol. This strategy effectively oxidizes Si–H bonds, affording Si–O bonds. Generally, the corresponding silanols can be obtained in moderate to good yields at room temperature under oxygen atmospheres, representing a green protocol to complement the existing preparation methods for silanols. Full article
(This article belongs to the Special Issue Novel Green Catalysts and Applications of Organocatalysis)
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