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State-of-the-Art Analytical Methods for Natural Products
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State-of-the-Art Analytical Methods for Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1670

Special Issue Editor

Dr. Dimitrina Zheleva-Dimitrova

E-Mail Website
Guest Editor
Pharmacognosy, Faculty of Pharmacy, Medical Unviersity, Sofia 1000, Bulgaria
Interests: phytochemical analysis; LC-MS; plant metabolomics; pharmacognosy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemical profiling and analytical methods are of particular interest in plant science. Over the last decade, intensive research in the field of specialized (secondary) plant metabolites led to the development of a variety of hyphenated techniques such as LC/UV, LC/MS and LC/NMR. These techniques analyze the chemical composition of plants and rapidly provide structural information, leading to the identification of compounds in many cases.

Plant-derived specialized metabolites are essential, as both the chemical and biological characterization of medicinal plants are greatly important. At present, numerous research groups are focusing on the study and characterization of herbal extracts to identify a variety of plant metabolites and their potential to exert protective effects on biological systems. Analytical methods that provide significant time savings, while preserving resolution and efficiency, and are highly desirable (and necessary) to enable a faster development of the new approach in an increasingly competitive landscape.

This Special Issue of Molecules provides an overview of the current analytical trends and recent advances in the characterization of natural plant products, with the aim of highlighting valuable insights into how we can overcome some of the analytical challenges associated with the next generation of natural product knowledge.

Please note that in studies on complex mixtures of natural products, the characterization of chemicals using analytical methodologies, such as HPLC, MS, LC–MS, HPLC–MS and NMR, should be included.

Dr. Dimitrina Zheleva-Dimitrova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemical analysis
  • hyphenated techniques
  • HPLC
  • LC-MS
  • LC-NMR
  • GC-MS
  • secondary metabolites
  • natural products analysis

Published Papers (2 papers)

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Research

17 pages, 6610 KiB  
Article
An Evaluation of the Impact of 60Co Irradiation on Volatile Organic Compounds of Olibanum Using Gas Chromatography Ion Mobility Spectrometry
by Qiao Luo, Shanshuo Liu, Ye He, Jiayao Liu, Xinyu Zhang, Liqiu Zheng and Dan Huang
Molecules 2024, 29(7), 1671; https://doi.org/10.3390/molecules29071671 - 08 Apr 2024
Viewed by 425
Abstract
Olibanum is a resinous traditional Chinese medicine that is directly used as a powder. It is widely used in China and is often combined with other traditional Chinese medicine powders to promote blood circulation and relieve pain, as well as to treat rheumatism, [...] Read more.
Olibanum is a resinous traditional Chinese medicine that is directly used as a powder. It is widely used in China and is often combined with other traditional Chinese medicine powders to promote blood circulation and relieve pain, as well as to treat rheumatism, rheumatoid arthritis, and osteoarthritis. Powdered traditional Chinese medicine is often easily contaminated by microorganisms and 60Co irradiation is one of the good sterilization methods. Volatile organic compounds (VOCs) are the main active ingredient of olibanum. The aim of this study was to validate the optimum doses of 60Co irradiation and its effect on VOCs. 60Co irradiation was applied in different doses of 0 kGy, 1.5 kGy, 3.0 kGy, and 6.0 kGy. Changes in VOCs were detected using gas chromatography ion mobility spectrometry. A total of 81 VOCs were identified. The odor fingerprint results showed that, with an increase in irradiation dose, most of the VOCs of olibanum changed. Through principal component analysis, cluster analysis, and partial least squares discriminant analysis, it was demonstrated that, at 1.5 kGy, the impact of radiation on the VOCs of olibanum was minimal, indicating this is a relatively good irradiation dose. This study provides a theoretical basis for the irradiation processing and quality control of resinous medicinal materials such as olibanum and it also provides a good reference for irradiation technology development and its application to functional foods, thus making it both significant from a research perspective and useful from an application perspective. Full article
(This article belongs to the Special Issue State-of-the-Art Analytical Methods for Natural Products)
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21 pages, 2445 KiB  
Article
A Comprehensive Phytochemical Analysis of Sideritis scardica Infusion Using Orbitrap UHPLC-HRMS
by Dimitrina Zheleva-Dimitrova, Yulian Voynikov, Reneta Gevrenova and Vessela Balabanova
Molecules 2024, 29(1), 204; https://doi.org/10.3390/molecules29010204 - 29 Dec 2023
Cited by 2 | Viewed by 764
Abstract
Sideritis scardica Griseb, also known as “mountain tea” and “Olympus tea” (Lamiaceae family) is an endemic plant from the mountainous regions of the Balkan Peninsula. In this study, we focused on an in-depth phytochemical analysis of S. scardica infusion using ultra-high-performance liquid chromatography [...] Read more.
Sideritis scardica Griseb, also known as “mountain tea” and “Olympus tea” (Lamiaceae family) is an endemic plant from the mountainous regions of the Balkan Peninsula. In this study, we focused on an in-depth phytochemical analysis of S. scardica infusion using ultra-high-performance liquid chromatography hyphenated with high-resolution mass spectrometry (UHPLC–HRMS). Quantitative determination of the main secondary metabolites was carried out by UHPLC–HRMS analyses using the external standard method. The results revealed more than 100 metabolites, including five sugar acids and saccharides, 21 carboxylic, hydroxybenzoic, hydroxycinnamic acids, and derivatives, 15 acylquinic acids, 10 phenylpropanoid glycosides, four iridoid glycosides, 28 flavonoids, seven fatty acids, and four organosulfur compounds. Furthermore, a dereplication and fragmentation patterns of five caffeic acids oligomers and four acylhexaric acids was performed for the first time in S. scardica. Regarding the quantitative analysis, the phenylethanoid verbascoside (53) (151.54 ± 10.86 mg/g lyophilized infusion, li), the glycosides of isoscutellarein (78) (151.70 ± 14.78 mg/g li), methylisoscutelarein (82) (107.4 ± 9.07 mg/g li), and hypolaetin (79) (78.33 ± 3.29 mg/g li), as well as caffeic acid (20) (87.25 ± 6.54 mg/g li), were found to be the major compounds in S. scardica infusion. The performed state-of-the-art phytochemical analysis of S. scardica provides additional knowledge for the chemical constituents and usage of this valuable medicinal plant. Full article
(This article belongs to the Special Issue State-of-the-Art Analytical Methods for Natural Products)
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