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Coumarin and Its Derivatives III

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 900

Special Issue Editor


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Guest Editor
Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Interests: coumarins; natural product chemistry; organic chemistry; medicinal chemistry; chemical biology; computational chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Coumarin is a privileged scaffold in medicinal chemistry. Its derivatives are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. This scaffold is a unique and versatile oxygen-containing heterocyclic structure, presenting a large conjugated system with electron-rich and charge transport properties. These properties are responsible for the interaction of this scaffold with other molecules, such as biomolecules and ions. Therefore, a great number of coumarin derivatives have been designed, synthetized, and evaluated against different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications with which to monitor enzyme activity and complex biological events in a timely manner, as well as accurately monitor pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recently synthetic pathways, along with the main biological applications and theoretical studies, are welcome for this Special Issue.

Dr. Maria João Matos
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coumarins
  • natural products
  • synthesis
  • bioactivity
  • fluorescent dyes
  • computational studies
  • analytical methods
  • medicinal chemistry
  • chemical biology
  • drug discovery

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Published Papers (1 paper)

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Research

9 pages, 3148 KiB  
Article
Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors
by Gyeong Han Jeong, Manisha Yadav, Seung Sik Lee, Byung Yeoup Chung, Jae-Hyeon Cho, In-Chul Lee, Hyoung-Woo Bai and Tae Hoon Kim
Molecules 2024, 29(2), 341; https://doi.org/10.3390/molecules29020341 - 10 Jan 2024
Viewed by 632
Abstract
A representative naturally occurring coumarin, 4-methylumbelliferone (5), was exposed to 50 kGy of gamma ray, resulting in four newly generated dihydrocoumarin products 14 induced by the gamma irradiation. The structures of these new products were elucidated by interpretation of [...] Read more.
A representative naturally occurring coumarin, 4-methylumbelliferone (5), was exposed to 50 kGy of gamma ray, resulting in four newly generated dihydrocoumarin products 14 induced by the gamma irradiation. The structures of these new products were elucidated by interpretation of spectroscopic data (NMR, MS, [α]D, and UV). The unusual bisdihydrocoumarin 4 exhibited improved tyrosinase inhibitory capacity toward mushroom tyrosinase with IC50 values of 19.8 ± 0.5 μM as compared to the original 4-methylumbelliferone (5). A kinetic analysis also exhibited that the potent metabolite 4 had non-competitive modes of action. Linkage of the hydroxymethyl group in the C-3 and C-4 positions on the lactone ring probably enhances the tyrosinase inhibitory effect of 4-methylumbelliferone (5). Thus, the novel coumarin analog 4 is an interesting new class of tyrosinase inhibitory candidates that requires further examination. Full article
(This article belongs to the Special Issue Coumarin and Its Derivatives III)
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