Understanding Protein/Peptide Self-Assembly Using Structural and Biophysical Chemistry 2.0

Dear Colleagues,

Protein and peptide self-assembly is an emerging area of research at the triple point where chemistry, biology, and physics meet.

Protein self-assembly makes up functional as well as pathological superstructures in living cells. For example, amyloid oligomers, protofilaments, and fibrils are associated with prions, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, among others. Moreover, secondary structure transition and self-assembly of synthetic peptides into gels, fibrils, fibers, tubules, or sheets have found applications in tissue engineering and biomedical devices.

The purpose of this Special Issue is to show the power of biophysical chemistry as an interdisciplinary approach to elucidate at the molecular level the process of self-assembly/aggregation in proteins and peptides. Advances in understanding protein/peptide self-assembly with a multi-technique methodology are particularly welcome. Additionally, emerging experimental and computational research that offers new concepts, models, and strategies is encouraged. Contributions to this Special Issue in the form of original research, communications, perspectives, hypotheses, and review articles that favor advances in this fascinating area of research are cordially invited.

Dr. Veronica Dodero
Dr. Maria Georgina Herrera
Dr. Maria Julia Amundarain
Guest Editors

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Areas of interest in protein/peptide:

• self-assembly
• aggregates and their interaction with biological systems
• aggregation in cells
• folding/misfolding
• intrinsically disordered systems
• liquid–liquid phase separation
• molecular modeling (molecular dynamics, docking)
• development of characterization techniques (microscopy, spectroscopy, modeling, etc.)

• Understanding Protein/Peptide Self-Assembly Using Structural and Biophysical Chemistry 2.0 in Molecules
• Understanding Protein/Peptide Self-Assembly Using Structural and Biophysical Chemistry 2.0 in Molecules