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Small Molecules as Targeted Anticancer Agents

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1044

Special Issue Editors


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Guest Editor
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
Interests: ruthenium(II) complexes; anticancer drugs; G-quadruplex DNA; DNA damage/repair; PI3K/AKT signal pathway
Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510006, China
Interests: anti-cancer drugs; G-quadruplex ligands; EGFR-mutation inhibitors; Ruthenium(II) complexes; Copper(II) complexes

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Guest Editor
Department of Physiology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
Interests: tumor preventing and controlling; anticancer drug screening; anti-tumor mechanism; cell signaling transduction

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Guest Editor
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
Interests: pharmacology; zebrafish; anticancer; signaling pathway; nanoparticles medicine

Special Issue Information

Dear Colleagues,

Small molecules have attracted significant attention for their success in tumor-targeting drugs in clinic. Recent efforts have facilitated the development of novel small molecules acting as potential anti-cancer drugs, and amazing progress has been made.

This Special Issue welcomes all research on small molecules as promising anti-tumor agents, including works that are concerned with the design, synthesis and characterization of small molecules, such as organic and inorganic compounds and metallic complexes; in vitro and in vivo anticancer activity against varied tumor cells; the inhibitory effect on the migration and metastasis of various tumor cells, toxicity and multidrug resistance; and the underlying mechanisms of DNA damage/repair, apoptosis, autophagy and ferroptosis; the mechanisms of signaling pathway regulation; the interactions of small molecules with biology macro-molecules; goal verification; and so on.

Prof. Dr. Wenjie Mei
Dr. Qiong Wu
Dr. Jin-lan Meng
Dr. Chengxi Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • small molecules
  • anticancer
  • inhibitor
  • target
  • signal pathway
  • DNA damage/repair

Published Papers (1 paper)

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Research

15 pages, 2613 KiB  
Article
Preparation, Characterization, and Antioxidant Activities of Extracts from Amygdalus persica L. Flowers
by Qingtao Yu, Wenzhi Li, Ming Liang, Guohu Li, Zhuoyan Wu, Jieyi Long, Chanling Yuan, Wenjie Mei and Xiaole Xia
Molecules 2024, 29(3), 633; https://doi.org/10.3390/molecules29030633 - 29 Jan 2024
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Abstract
A novel water-soluble Amygdalus persica L. flowers polysaccharide (APL) was successfully isolated and purified from Amygdalus persica L. flowers by hot water extraction. Its chemical components and structure were analyzed by IR, GC-MS, and HPLC. APL consisted of rhamnose, arabinose, mannose and glucose [...] Read more.
A novel water-soluble Amygdalus persica L. flowers polysaccharide (APL) was successfully isolated and purified from Amygdalus persica L. flowers by hot water extraction. Its chemical components and structure were analyzed by IR, GC-MS, and HPLC. APL consisted of rhamnose, arabinose, mannose and glucose in a molar ratio of 0.17:0.034:1.0:0.17 with an average molecular weight of approximately 208.53 kDa and 15.19 kDa. The antioxidant activity of APL was evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 3-ethylbenzthiazoline-6-sulfonic acid (ABTS), Hydroxyl radical scavenging, Superoxide radical scavenging, and the reducing power activity was also determined in vitro. Besides, in vivo antioxidant experiment, zebrafish (Danio rerio) embryos were treated with different concentrations of APL and then exposed to LPS to induce oxidative stress. Treatment with APL at 50 or 100 µg/mL significantly reduced LPS-induced oxidative stress in the zebrafish, demonstrating the strong antioxidant activity of APL. Moreover, the effect of APL on zebrafish depigmentation was tested by analyzing the tyrosinase activity and melanin content of zebrafish embryos. APL showed a potential reduction in the total melanin content and tyrosinase activity after treatment. This work provided important information for developing a potential natural antioxidant in the field of cosmetics and food. Full article
(This article belongs to the Special Issue Small Molecules as Targeted Anticancer Agents)
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