molecules-logo

Journal Browser

Journal Browser

Stereoselective Organic Synthesis: New Tools, New Perspectives

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 1565

Special Issue Editor


E-Mail Website
Guest Editor
School of Science and Technology, Chemistry Division, University of Camerino, Camerino, Italy
Interests: stereoselective synthesis; Lewis acid catalysis; multicomponent reactions; small molecules; heterocycle synthesis; green chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Organic chemistry has explored its potential, especially in the field of stereoselective synthesis. Nowadays, there is no doubt that the biological activity of each enantiomer in living beings is different, and consequently, the need for enantiopure substances to be used as pharmaceuticals as well as pesticides, insecticides, flavors, and fragrances is increasing. Furthermore, sustainability is currently a major issue , meaning that the development of chiral catalysts that allow for huge amounts of enantioenriched or enantiopure substances with even smaller amounts of catalyst and even higher turnover number to be prepared has become a pressing issue.

These needs have prompted synthetic organic chemists to achieve deep insight and comprehension of all of the factors influencing the outcomes of compound synthesis. From this point of view, the dissemination of the results obtained in the field of stereoselective synthesis offers the community new opportunities to widen our knowledge of mechanisms and methods and to enrich the collection of the synthetic tools available. We welcome selected papers that are able to introduce new perspectives to increase our comprehension of the effects involved in the mechanism of the stereoselective synthesis of pharmaceuticals, pesticides, insecticides, flavors and fragrances, and chiral catalysts via their application.

Dr. Cimarelli Cristina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stereoselective synthesis
  • asymmetric catalysis
  • asymmetric organocatalysis
  • enantiodifferentiation
  • reaction mechanism
  • chiral auxiliaries
  • chiral complexes
  • synthetic methodologies

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 1872 KiB  
Communication
Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
by Ewelina Kowalska, Lesław Sieroń and Anna Albrecht
Molecules 2022, 27(20), 6809; https://doi.org/10.3390/molecules27206809 - 11 Oct 2022
Viewed by 1220
Abstract
Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative [...] Read more.
Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative (3+2)-cyclization. Full article
(This article belongs to the Special Issue Stereoselective Organic Synthesis: New Tools, New Perspectives)
Show Figures

Scheme 1

Back to TopTop