Multicomponent Reactions in Organic Synthesis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 8099
Special Issue Editors
Interests: MCRs; heterocycles synthesis; bispidines; polymers modification; nanoparticles; hydrogels; medicinal chemistry
Special Issue Information
Dear Colleagues,
The first Multicomponent Reaction (MCR) dates back to the mid-19th century, when Adolph Stecker was able to perform the synthesis of the amino acid Alanine by “simply” mixing acetaldehyde with ammonia and hydrogen cyanide. In the following decades, several other MCRs were developed including, for instance, the Hantzsch pyrrole synthesis, the Biginelli and Mannich reactions, as well as the chemical synthesis of the natural product tropinone. Later on, Passerini and Ugi enriched the world of MCRs by introducing important isocyanide-based synthesis.
The reason why, almost two centuries after their first appearance, MCRs are still being investigated and draw so much attention is due to the fact that they have some advantages over classical chemical synthetic routes. First, their atom economy is remarkable; in fact, they are convergent reactions, since most of the atoms of the reagents are incorporated into the product. Second, the synthetic methodology of a MCR is generally applicable to a wide range of starting materials, therefore it is well suited for parallel syntheses, allowing the generation of relatively large libraries of compounds. Moreover, unlike the classical syntheses of complex organic molecules, in MCRs the main standard operations, such as reaction setup, work-up and purification steps have to be performed just once. Finally, the number of compounds that can be formed is enormous, with the chemical space largely not overlapping the one accessible through classical synthesis. Thus, as a consequence of their advantages, MCRs are a useful tool for creating diversity and complexity in the synthesis of organic molecules. They represent the cornerstones of both combinatorial chemistry and diversity-oriented synthesis, and can be applied in the development of modern synthetic methodology, for instance in the pharmaceutical and drug discovery research. Nowadays, the strong demand for new chemical compounds, such as innovative antimicrobials, asks for the development of original synthetic strategies for the easy and fast generation of wide molecules libraries.
Nevertheless, MCRs are still often neglected and underestimated by the organic chemistry, in favor of the classical synthetic methods.
The aim of this Special Issue is to bring to light this topic, to underline how useful and powerful MCRs can be, especially in research. Therefore, this Special Issue will gather scientific papers on novel MCRs mechanisms, innovative structures achieved by means of MCRs and useful applications of MCRs in organic synthesis and materials modifications.
Dr. Arianna Rossetti
Prof. Dr. Alessandro Sacchetti
Guest Editors
Manuscript Submission Information
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Keywords
- multicomponent reactions
- heterocycles synthesis
- cascade reactions
- one-pot
- lead compounds
- chemical space exploration
- organic synthesis
