Advances in Antibacterial Molecules

Dear Colleagues,

Bacteria are the cause of different infectious diseases that have an impact on public health worldwide, causing high morbidity and mortality rates. In the past, many drugs have been developed to prevent and control these infectious diseases. However, in the few last decades, multidrug resistance (MDR) has emerged as a significant public health problem that must be addressed. Despite its importance, current pharmacological treatment has unreliable efficacy against the group of bacteria denominated ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.). Therefore, there is an urgent need to develop new therapeutic options that are safer and more effective to combat MDR.

In the last two decades, new strategies in drug discovery have been implemented to combat infectious diseases. Despite these facts and the impressive advances in understanding the biology of these diseases, only a limited number of compounds are currently in clinical trials. Therefore, there is an urgent need to develop new therapeutic options that will help to combat MDR, increase effectiveness, decrease cost, and facilitate availability.

This research topic seeks manuscripts dealing with novel approaches in the discovery and development of drugs for infectious diseases. By considering both original research and review articles that could have an ever-increasing impact on the drug discovery pipeline, new trends could be discovered that would impact the field. Areas to be covered in this research topic may include but are not limited to the following:

• Bioactive compounds;
• Computer-aided drug design;
• Synthesis and biological activity of small molecules;
• Drug targets;
• Drug repositioning.

Prof. Dr. Gildardo Rivera Sanchez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bacteria
• drug design
• drug repositioning
• molecular docking
• molecular dynamics
• bioinformatics
• synthesis
• biomolecules
• targets
• in vitro assays
• in vivo assays
• small molecules
• peptides
• natural products
• mechanism of action