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Design, Synthesis and Evaluation of Small Molecule Drugs

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 668

Special Issue Editors


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Guest Editor
Department of Public Health, University of Naples Federico II, Naples, Italy
Interests: drug design; synthesis and characterization of molecules; medicinal chemistry; serotoninergic ligands; NCX isoform modulators

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Naples, Italy
Interests: drug design; synthesis and characterization of molecules; medicinal chemistry; NCX isoform modulators; H2S donors

Special Issue Information

Dear Colleagues,

Small molecule drugs have been the mainstay of the pharmaceutical industry for nearly a century. Defined as any organic compound with a low molecular weight, small molecule drugs have some distinct advantages as therapeutics: most can be administered orally, and they can pass through cell membranes to reach intracellular targets. They can also be designed to engage biological targets by various modes of action and their distribution can further be tailored, for example, to allow for systemic exposure with or without brain penetration. The rapid advancement of biopharmaceutical research and technology opens up possibilities for innovative and creative new approaches to developing small molecule drugs. Based on these considerations, this Special Issue aims to provide a platform for original research papers, short communications, and review articles on the latest advances in small molecule drugs. These papers may cover multidisciplinary aspects (such as drug design, synthesis, and pharmacological evaluation) of novel small molecule drugs with potential therapeutic innovations.

Dr. Elisa Magli
Prof. Dr. Beatrice Severino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • small molecule drugs
  • synthesis
  • characterization
  • medicinal chemistry
  • biological activity
  • drug delivery

Published Papers (1 paper)

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Research

10 pages, 1824 KiB  
Article
3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration
by Rosa Sparaco, Pierfrancesco Cinque, Antonia Scognamiglio, Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Paolo Luciano, Marcello Casertano, Anna Aiello, Gustavo Yuri Martins Viegas, Gilberto De Nucci and Francesco Frecentese
Molecules 2024, 29(7), 1598; https://doi.org/10.3390/molecules29071598 - 03 Apr 2024
Viewed by 401
Abstract
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats. As part of our follow-up to this study, herein, [...] Read more.
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats. As part of our follow-up to this study, herein, we describe the first synthesis of (±)-3-nitroatenolol as a probe to evaluate the potential nitration of atenolol by endothelium. Chiral chromatography was used to produce pure enantiomers. By using Riguera’s method, which is based on the sign distribution of ΔδH, the absolute configuration of the secondary alcohol was determined. Full article
(This article belongs to the Special Issue Design, Synthesis and Evaluation of Small Molecule Drugs)
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