Antimicrobial Activity of Natural Products
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 October 2021)
Special Issue Editor
Interests: bioactivity; antimicrobials; mode-of-action and target ID; AMR; natural products; screening; zebrafish models; DMPK
Special Issue Information
Dear Colleagues,
Natural products play an important role in various pharmaceutical applications. In particular, secondary metabolites from plant, microbial, and marine origin continue to contribute to the discovery of novel drugs, e.g., in the fields of oncology and antibiotic therapy. Natural products are so-called “preferred scaffolds” as they often exhibit new modes-of-action and they are considered as evolutionarily optimized to pass biological membrane barriers, the latter making them particularly successful in whole cell-based screening. Over the last four decades, natural products and derivatives thereof made up approximately 50% of all newly approved antibacterial drugs and natural product-based antiinfective molecules were also developed as antiparasitic, antifungal, and antiviral drugs. More recently, natural products are being explored for their use as antivirulence agents (pathoblockers) and as warheads in antibiotic drug-conjugates (the “Trojan horse” strategy). Importantly, sources of new natural products are by far not exhausted and the majority of the world’s biodiversity remains to be explored. Increasing the biodiversity of natural product producers will typically also increase chemical diversity. In turn, screening of chemical diverse scaffolds greatly increases the probability of discovering novel targets and new mechanisms of action. This Special Issue on “Antimicrobial Activities of Natural Products” aims to cover recent progress and trends in the field of natural product discovery with a focus on molecules exhibiting antimicrobial activity. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of antimicrobial natural products. Multidisciplinary studies on new natural products and derivatives are particularly welcome.
Dr. Jennifer Herrmann
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Natural products and derivatives
- Antibacterial compounds
- Antifungal compounds
- Antimicrobial targets
- Screening
- Target identification
- Antimicrobial resistance
- Multi-drug resistant pathogens
- Structure-activity relationships
- Marine natural product producers
- Plant natural products
- Microbial natural product producers
