Submit to Molecules Review for Molecules Propose a Special Issue

Journal Browser

► Journal Browser

Biopolymers Processing for Drug Delivery, Wound Healing and Regenerative Medicine

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (22 October 2021) | Viewed by 7712

Share This Special Issue

Special Issue Editors

Dr. Carlos A. García-González

E-Mail Website1 Website2
Guest Editor

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Interests: aerogels; supercritical fluids; regenerative medicine; pharmaceutical technology; 3D-bioprinting; porous materials; scaffolds; biomedical applications
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Pasquale Del Gaudio

E-Mail Website
Guest Editor

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
Interests: hydrogels; aerogels; controlled drug delivery; wound healing; carbohydrate polymers; microparticles; nanoparticles; nanocomposite; 3D printing
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Ana Leite Oliveira

E-Mail Website1 Website2
Guest Editor

Biomaterials and Biomedical Technology Lab, CBQF – Centro de Biotecnologia e Química Fina, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, 4169-005 Porto, Portugal
Interests: biopolymers; silk-based biomaterials; wound healing and regeneration; sterilization of sensitive biomedical polymers
Special Issues, Collections and Topics in MDPI journals

Dr. Ricardo Starbird

E-Mail Website
Guest Editor

Escuela de Química, Instituto Tecnológico de Costa Rica, 30102 Cartago, PO Box 159-7050, Costa Rica
Interests: polymer science; structuration of biomass and conductive polymers; composites and electrochemical sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biopolymers, including natural (e.g., polysaccharides, proteins, gums, natural rubbers, bacterial polymers), synthetic (e.g., aliphatic polyesters and polyphosphoester) and biocomposites are of paramount interest in regenerative medicine and wound healing due to their availability, processability, degradability, low toxicity, and biological response. Moreover, the engineering of biopolymer-based materials at nano- and microscale along with their chemical properties is crucial in the design and development of advanced carriers for bioactive molecules. Finally, combination products including or based on biopolymers for controlled drug release offer a powerful solution to improve the tissue integration and biological response of these materials. Understanding the drug delivery mechanisms and therapeutic effect of such systems is useful for the development of advanced therapies with improved performance for pharmaceutical technology, wound healing, and regenerative medicine.

The main aim of the Special Issue on “Biopolymer Processing for Drug Delivery, Wound Healing and Regenerative Medicine” is to gather recent findings and current advances in biopolymer research for biomedical applications, particularly in regenerative medicine, wound healing, and drug delivery. Contributions to this issue can be original research or review articles and may cover all aspects of biopolymer research, ranging from the chemical synthesis and characterization of modified biopolymers, their processing in different morphologies and hierarchical structures, as well as their assessment for biomedical uses.

This Special Issue is an initiative of the AERoGELS (CA18125—Advanced Engineering and Research of aeroGels for Environment and Life Sciences) Action (https://cost-aerogels.eu) by COST (European Cooperation in Science and Technology) that aims to boost the development of aerogels for biomedical and environmental applications by setting up a multidisciplinary knowledge-based network from technological, scientific, and market points of view.

Dr. Carlos A. García-González
Prof. Pasquale Del Gaudio
Prof. Dr. Ana Leite Oliveira
Dr. Ricardo Starbird
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Biopolymer
Drug delivery
Regenerative medicine
Wound healing
Biodegradation
Nanostructured carriers

Published Papers (2 papers)

Download All Papers

Research

Jump to: Review

27 pages, 8372 KiB

Open AccessArticle

Microencapsulated Isoniazid-Loaded Metal–Organic Frameworks for Pulmonary Administration of Antituberculosis Drugs

by Cristina Fernández-Paz, Estefanía Fernández-Paz, Pablo Salcedo-Abraira, Sara Rojas, Sheila Barrios-Esteban, Noemi Csaba, Patricia Horcajada and Carmen Remuñán-López

Molecules 2021, 26(21), 6408; https://doi.org/10.3390/molecules26216408 - 23 Oct 2021

Cited by 10 | Viewed by 2770

Abstract

Tuberculosis (TB) is an infectious disease that causes a great number of deaths in the world (1.5 million people per year). This disease is currently treated by administering high doses of various oral anti-TB drugs for prolonged periods (up to 2 years). While this regimen is normally effective when taken as prescribed, many people with TB experience difficulties in complying with their medication schedule. Furthermore, the oral administration of standard anti-TB drugs causes severe side effects and widespread resistances. Recently, we proposed an original platform for pulmonary TB treatment consisting of mannitol microspheres (Ma MS) containing iron (III) trimesate metal–organic framework (MOF) MIL-100 nanoparticles (NPs). In the present work, we loaded this system with the first-line anti-TB drug isoniazid (INH) and evaluated both the viability and safety of the drug vehicle components, as well as the cell internalization of the formulation in alveolar A549 cells. Results show that INH-loaded MOF (INH@MIL-100) NPs were efficiently microencapsulated in Ma MS, which displayed suitable aerodynamic characteristics for pulmonary administration and non-toxicity. MIL-100 and INH@MIL-100 NPs were efficiently internalized by A549 cells, mainly localized in the cytoplasm. In conclusion, the proposed micro-nanosystem is a good candidate for the pulmonary administration of anti-TB drugs. Full article

(This article belongs to the Special Issue Biopolymers Processing for Drug Delivery, Wound Healing and Regenerative Medicine)

► Show Figures

Figure 1

Review

Jump to: Research

29 pages, 6895 KiB

Open AccessReview

Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds

by Beatriz G. Bernardes, Pasquale Del Gaudio, Paulo Alves, Raquel Costa, Carlos A. García-Gonzaléz and Ana Leite Oliveira

Molecules 2021, 26(13), 3834; https://doi.org/10.3390/molecules26133834 - 23 Jun 2021

Cited by 32 | Viewed by 4293

Abstract

Wounds affect one’s quality of life and should be managed on a patient-specific approach, based on the particular healing phase and wound condition. During wound healing, exudate is produced as a natural response towards healing. However, excessive production can be detrimental, representing a challenge for wound management. The design and development of new healing devices and therapeutics with improved performance is a constant demand from the healthcare services. Aerogels can combine high porosity and low density with the adequate fluid interaction and drug loading capacity, to establish hemostasis and promote the healing and regeneration of exudative and chronic wounds. Bio-based aerogels, i.e., those produced from natural polymers, are particularly attractive since they encompass their intrinsic chemical properties and the physical features of their nanostructure. In this work, the emerging research on aerogels for wound treatment is reviewed for the first time. The current scenario and the opportunities provided by aerogels in the form of films, membranes and particles are identified to face current unmet demands in fluid managing and wound healing and regeneration. Full article

(This article belongs to the Special Issue Biopolymers Processing for Drug Delivery, Wound Healing and Regenerative Medicine)

► Show Figures