Chalcone: A Privileged Structure in Medicinal Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 91280
Special Issue Editors
Interests: drug design; hybrid molecules; Alzheimer’s disease; AChE inhibitors; FAAH inhibitors; CB receptors ligands; flavonoids
Special Issues, Collections and Topics in MDPI journals
Interests: flavonoids; drug design; hybrid molecules; MDR reversal; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chalcones belong to the flavonoid family and are widely distributed in edible plants. Naturally-occurring chalcones are endowed with a broad spectrum of biological activities and have been used in traditional medicine for many years. These natural products can be defined “privileged structures” and, as such, they can be properly exploited to develop effective strategies in drug discovery. The design and synthetic feasibility of chalcone-based compounds provides a new world of possibilities to find novel biological activities and unexplored therapeutic applications. Indeed, the peculiar electrophilic trans-α,β-unsaturated carbonyl framework of chalcone allows the molecule to interact with cysteine residues of different biological targets. Furthermore, because of their conjugated system, chalcones can be fluorescent, making them potential chemical probes for mechanistic investigations and imaging/diagnosis. This Special Issue aims to provide an overview of the latest applications of this intriguing class of natural/synthetic compounds in medicinal chemistry.
Prof. Dr. Angela Rampa
Prof. Dr. Alessandra Bisi
Guest Editors
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Keywords
- chalcone
- antioxidant
- anticancer
- anti-inflammatory
- antibacterial
- antimicrobial
- neuroprotective effects
- antimalarial
- antidiabetic
- Probes