Chemopreventive and Antioxidant Activity of Plant Extracts and Other Phytochemical Compounds

Dear Colleagues,

Chemoprevention is the use of natural or synthetic chemical agents to reverse, suppress or prevent carcinogenic progression to invasive cancer. Many chemopreventive agents are plant compounds that have protective or disease-preventive properties. Moreover, natural compounds exert chemoprevention through the modulation of cells’ redox statuses. In several cases, these changes in the cellular redox environment may lead to completely different outcomes. For example, some phytochemicals may act as antioxidants and offer protection against ROS-induced DNA damage, thus preventing mutagenesis and the initiation of carcinogenesis. On the other hand, there are natural compounds that induce the apoptosis of cancer cells by acting as pro-oxidants. We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together the latest research and critical thinking concerning the complex and interesting interplay between the antioxidant/pro-oxidant and chemopreventive activities of compounds of natural origin. These natural compounds may be individual substances or chemical mixtures derived from either terrestrial or marine sources.

Dr. Dimitrios Stagos
Dr. Nikolaos Goutzourelas
Dr. Varvara Trachana
Guest Editors

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• plant extracts
• natural compounds
• antioxidants
• anticancer
• polyphenols
• ROS-induced DNA damage