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Molecules
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Functional Nanomaterials in Analytical and Biomedical Sciences
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Functional Nanomaterials in Analytical and Biomedical Sciences

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5533

Special Issue Editors

Dr. Suresh Kumar Kailasa

E-Mail Website
Guest Editor
Department of Chemistry, Sardar Vallabhbhai National Institute of Technology (SVNIT) Surat, Gujarat 395 007, India
Interests: carbon dots; nanosensors; functional nanomaterials; drug delivery; microextraction; biomarker detection; MALDI-MS; analytical chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Janardhan Reddy Koduru

E-Mail Website
Guest Editor
Department of Environmental Engineering, Kwangwoon University, Seoul, 01897, Korea
Interests: carbon based material; carbon dots; functional nanomaterials; water remediation; colorimetric sensors; biocomposites; extraction; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, functionalization of nanomaterials with surface active ligands has attracted significant interest in multidisciplinary research. Further, functional nanomaterials have shown remarkable and exciting opportunities in analytical and biomedical sciences, where they have been used for sensing of wide variety of target analytes, as adsorbents for the removal of toxic chemicals, and as promising materials for drug delivery and bioimaging applications. Functional nanomaterials play an important role in addressing challenges related to analytical chemistry, especially selectivity, sensitivity, miniaturization, microextraction, and separation. By functionalizing nanomaterials with various ligands/nanostructures, a wide variety of multifunctional nanomaterials have been synthesized for various applications from analytical to biomedical sciences.

This Special Issue focuses on the synthesis of functional nanomaterials and their applications in analytical (sensing, separation, and removal of chemical species) and biomedical (drug delivery, bioimaging, and tissue engineering) sciences.

Potential topics include (but are not limited to) the following:

  • Functionalization of nanomaterials;
  • Nanosensors;
  • Nanoadsorbents;
  • Drug delivery;
  • Nanomaterials-based microextractions;
  • Green synthesis of functional nanomaterials;
  • Tissue engineering;
  • Bioimaging;
  • Functional nanomaterials in environmental chemistry;
  • Functional nanomaterials in advanced biomedical sciences;
  • Functional nanomaterials in separation science.

Dr. Suresh Kumar Kailasa
Dr. Janardhan Reddy Koduru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional nanomaterials
  • nanosensors
  • nanoadsorbents
  • drug delivery
  • microextraction
  • tissue engineering
  • bioimaging
  • separation science

Published Papers (3 papers)

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Research

11 pages, 3849 KiB  
Article
Synthesis of Multifunctional Eu(III) Complex Doped Fe3O4/Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging
by Hoang Thi Khuyen, Tran Thu Huong, Nguyen Duc Van, Nguyen Thanh Huong, Nguyen Vu, Pham Thi Lien, Pham Hong Nam and Vu Xuan Nghia
Molecules 2023, 28(2), 749; https://doi.org/10.3390/molecules28020749 - 11 Jan 2023
Cited by 5 | Viewed by 1643
Abstract
In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate)3 was integrated with Fe3O4 and gold (Au) nanoparticles to form a multifunctional nanocomposite, Fe3O4/Au/Eu(TTA)3 (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH [...] Read more.
In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate)3 was integrated with Fe3O4 and gold (Au) nanoparticles to form a multifunctional nanocomposite, Fe3O4/Au/Eu(TTA)3 (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH2, the FOASET NC exhibits a small size of 60–70 nm and strong, sharp emission at λmax = 614 nm, enhanced by surface plasmon resonance (SPR) of Au nanoparticles that provided an effective label for HT29 colorectal cancer cells by fluorescence microscopy imaging. In addition, a hyperthermia temperature (42–46 °C) was completely achieved by using these FOASET NCs in an aqueous solution with three heating modes for (i) Magnetic therapy (MT), (ii) Photothermal therapy (PT), and (iii) Dual magnetic-photothermal therapy (MPT). The heating efficiency was improved in the dual magnetic-photothermal heating mode. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Analytical and Biomedical Sciences)
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13 pages, 3674 KiB  
Article
Electrically Polarized Withaferin A and Alginate-Incorporated Biphasic Calcium Phosphate Microspheres Exhibit Osteogenicity and Antibacterial Activity In Vitro
by Itishree Priyadarshini, Subhasmita Swain, Janardhan Reddy Koduru and Tapash Ranjan Rautray
Molecules 2023, 28(1), 86; https://doi.org/10.3390/molecules28010086 - 22 Dec 2022
Cited by 11 | Viewed by 1391
Abstract
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications. These withaferin A and alginate-incorporated biphasic calcium phosphate (BCP-WFA-ALG) microspheres were then negatively polarized, [...] Read more.
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications. These withaferin A and alginate-incorporated biphasic calcium phosphate (BCP-WFA-ALG) microspheres were then negatively polarized, and the formation of biphasic calcium phosphates was validated by X-ray diffraction study. Although the TSDC measurement of the BCP-WFA-ALG microspheres showed the highest current density of 5.37 nA/cm2, the contact angle of the specimen was found to be lower than the control BCP microspheres in all the media. The water uptake into BCP-WFA-ALG microspheres was significantly higher than in the pure BCP microspheres. MTT assay results showed that there was a significant enhancement in cell proliferation rate with the BCP-WFA-ALG composite microspheres. The osteogenic differentiation of MG 63 cells on BCP-WFA-ALG microspheres exhibited an increased expression of osteogenic marker genes in the case of the BCP-WFA-ALG composite microspheres. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Analytical and Biomedical Sciences)
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13 pages, 1968 KiB  
Article
A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy
by Setumo Lebogang Thobakgale, Saturnin Ombinda-Lemboumba and Patience Mthunzi-Kufa
Molecules 2022, 27(8), 2554; https://doi.org/10.3390/molecules27082554 - 15 Apr 2022
Cited by 3 | Viewed by 1939
Abstract
In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide [...] Read more.
In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enhancement of the drugs using SERS. Aspirin (10% w/v) and tenofovir (20% v/v) were analysed in the presence of the nanomaterials to determine trends in molecular response to changes in gold/dextran concentrations. Qualitative analysis of the functional groups showed specific trends where the peak area increased with polarizability, electron density and decreased atomic radii. Steric hinderance effects also affected the trends in peak area due to the amount of gold/dextran nanoparticles in solution. Statistical analysis provided accurate and precise linear relationships (R2 = 0.99) for the ester and adenine functional groups of aspirin and tenofovir, respectively. From the above findings, the combined use of gold nano-scaffolds and gold/dextran nanomaterials amplified the Raman signal from the drugs to allow for systematic evaluation of their molecular properties. Although more experiments to correlate the findings are still needed, this SERS approach shows great potential as a screening method in the quality control of medications. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Analytical and Biomedical Sciences)
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