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Molecules
Special Issues
The Immunomodulatory Potential of Natural Compounds: Recent Advances
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The Immunomodulatory Potential of Natural Compounds: Recent Advances

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2453

Special Issue Editor

Dr. Hyeung-Jin Jang

E-Mail Website
Guest Editor
Professor, Head of Department of Biochemistry, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
Interests: nutrition and dietary components; herbal medicine; immunomodulatory potential of natural compounds; novel gene regulation; diabetes-related diseases; metabolic disease; inflammation; COPD; cancer therapy; cancer biology; regulation of p53; regulation of c-Myc
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural compounds are increasingly used for their antioxidant, anti-inflammatory, anticancer, bactericidal, and veridical properties for the benefit of human health. Although the number of publications dealing with natural compounds has increased significantly in recent years, it is true that there is still a lack of research on evaluating the efficacy of natural products.

Inflammation presents the latest international advances in experimental and clinical research on the physiology, biochemistry, cell biology, and pharmacology of inflammation. It can be either short-lived (acute) or long-lasting (chronic). Acute inflammation goes away within hours or days. Chronic inflammation can last months or years, even after the first trigger is gone. Conditions linked to chronic inflammation include cancer, heart disease, diabetes, asthma, COPD, and Alzheimer’s disease.

The aim of this Special Issue is to study, at a molecular level, the mechanisms of action of natural compounds (herbal medicine) in their various beneficial properties to human health and develop novel preventive and therapeutic agents against inflammation, metabolic disease, cancer, and other associated diseases.

We invite all scientists working on natural compounds (herbal medicine) to participate in this Special Issue. Original research articles or reviews on all aspects of the molecular and cellular mechanisms modulated by natural compounds (herbal medicine) are welcome.

We look forward to your contributions.

Prof. Dr. Hyeung-Jin Jang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds
  • nutrients
  • herbal medicine
  • inflammation
  • metabolic disease
  • cancer therapy
  • p53
  • c-Myc
  • novel gene
  • heart disease
  • asthma
  • COPD
  • Alzheimer’s disease

Published Papers (1 paper)

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Research

14 pages, 2035 KiB  
Article
The Regulating Effect of CII-3 and Its Active Components from Periplaneta americana on M1/M2 Macrophage Polarization
by Jinglei Xu, Yihao Che, Xinyue Liu, Chaohe Liu, Di Meng, Xiuqin Pang, Miao He, Guangming Liu, Chenggui Zhang, Dasong Yang and Huai Xiao
Molecules 2022, 27(14), 4416; https://doi.org/10.3390/molecules27144416 - 10 Jul 2022
Cited by 5 | Viewed by 1866
Abstract
CII-3 is the effective part of Periplaneta americana for application in oncotherapy. This study investigated its main chemical components for macrophage polarization regulation activity. Compounds were separated and purified, and their structures were elucidated based on NMR and HR-ESI-MS analyses. After inducing the [...] Read more.
CII-3 is the effective part of Periplaneta americana for application in oncotherapy. This study investigated its main chemical components for macrophage polarization regulation activity. Compounds were separated and purified, and their structures were elucidated based on NMR and HR-ESI-MS analyses. After inducing the M1 and M2 phenotype macrophages, CII-3 and testing components were added and co-incubated to evaluate their effects on the relevant markers of macrophages. Then, gradient concentrations of CII-3 and active monomers were further investigated for their effects on M2 macrophages. The effects were detected by RT-PCR, ELISA, flow cytometry, and immunofluorescence. Twelve compounds were identified from CII-3. CII-3 and pericanaside (5) had no obvious effect on M1 macrophages, while they significantly reduced the expression levels of M2 macrophage markers. Specifically, they significantly reduced the levels of TGF-β and IL-10 and the mRNA expression levels of ARG-1 and CD206 in the M2 phenotypes of RAW264.7 and Ana-1 macrophages. The conditioned medium of CII-3 and pericanaside (5) could inhibit the migration capacity of CT26.WT tumor cells. Macrophage M1/M2 polarization is a dynamic equilibrium, and the M2 phenotype, which can promote the growth of tumor cells, is relatively highly expressed in the tumor microenvironment. CII-3 and pericanaside could significantly reduce the phenotype of M2-type macrophages, indicating that the anti-tumor activity of CII-3 could be related to the inhibitory effect on M2 polarization, and pericanaside was one of the active components. Full article
(This article belongs to the Special Issue The Immunomodulatory Potential of Natural Compounds: Recent Advances)
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