Design and Synthesis of Novel Anti-Inflammatory Agents
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 9988
Special Issue Editors
Interests: medicinal chemistry; natural products; antioxidants; anti-inflammatory activity; pharmacokinetics; drug design; structure–activity relationships
Special Issues, Collections and Topics in MDPI journals
Interests: design, synthesis and pharmaceutical evaluation of hybrids of cinnamic acid with multiple biological profile
Special Issue Information
Dear Colleagues,
Inflammation is a physiological immune response to harmful stimuli. It is a protective mechanism which is phylogenetically highly conserved among humans and many other animal species and initiates the healing process to promote tissue recovery. Despite inflammation’s alliance with lifelong homeostasis, prolonged inflammation could be detrimental to health. Inflammatory mediators are associated with tissue damage and a compromised tissue repair process.
Inflammation is classified into acute and chronic depending on various inflammatory processes and cellular mechanisms. Recent findings suggest the important role of inadequate or chronic inflammation in the progression of chronic diseases and pathological conditions, such as arthritis, cancer, diabetes, cardiovascular diseases, eye disorders, obesity, autoimmune diseases, atherosclerosis, heart failure, and inflammatory bowel disease.
Two enzymes are implicated in the inflammatory process: cyclooxygenases and lipoxygenases. Additionally, it has been found that inflammation is associated with free radicals. During the inflammatory process, free radical homeostasis is disturbed. Free radicals are extremely reactive molecules with short lifetimes which react with different macromolecules such as nucleic acids, lipids, and proteins.
In recent years, ongoing research has been carried out regarding the discovery of novel potential anti-inflammatory agents. In this Special Issue, we aim to promote original research and reviews exploring recent progress in this field. Proposed topics include, among others, novel anti-inflammatory agents (natural or synthetic) and their evaluation and the clarification of molecular and biological mechanisms, enzymes, and targets implicated in anti-inflammatory responses.
Dr. Eleni Pontiki
Dr. Katerina Peperidou
Guest Editors
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Keywords
- anti-inflammatory agents
- natural products
- drug development
- structure–activity relationships
- interleukins
- cyclooxygenase
- lipoxygenase
- chronic diseases
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