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Metabolites of Terrestrial and Marine Origin on the Age-Related Disorders
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Metabolites of Terrestrial and Marine Origin on the Age-Related Disorders

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Metabolites".

Deadline for manuscript submissions: closed (30 April 2017) | Viewed by 29102

Special Issue Editor

Dr. Maria da Graça Costa G. Miguel

E-Mail Website
Guest Editor
Mediterranean Institute for Agriculture, Environment and Development, Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
Interests: bee products; medicinal plants; essential oils; anthocyanins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The sustained rise in human life expectancy has been significantly responsible for the increase of the risk of cancer, cardiovascular diseases, type II diabetes, obesity, neurodegenerative diseases, among other disorders. These age-related disorders may be considered as being one of the most challenging health problems in the world.

Several approaches have been reported to overcome and retard those age-related disorders, and one of them includes the use of herbal medicines and nutritional supplements not only for preventing age-related degeneration but also the cognitive decline. However, and more recently, works regarding the biological properties of marine natural products have increased. These studies have demonstrated that such marine natural compounds have promising and remarkable biological properties, which may triggered the discovery of new drugs for the management of some chronic diseases, generally found in the elderly people.

This Special Issue invites researchers to contribute to original research articles and review articles that address not only the primary and secondary metabolites of terrestrial plant but also those of marine origin with biological properties, which can be used either as supplements or herbal medicines, but also as potential drugs that can delay the morbidity and mortality characteristics of the age-related disorders.

Dr. Maria G. Miguel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • cardiovascular
  • diabetes
  • obesity
  • neurodegenerative
  • cognitive
  • inflammation
  • elderly
  • primary metabolites
  • secondary metabolites

Published Papers (4 papers)

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Research

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2213 KiB  
Article
Acetylcholinesterase Inhibitory Meroterpenoid from a Mangrove Endophytic Fungus Aspergillus sp. 16-5c
by Yuhua Long, Hui Cui, Xinglie Liu, Ze’en Xiao, Shitong Wen, Zhigang She and Xishan Huang
Molecules 2017, 22(5), 727; https://doi.org/10.3390/molecules22050727 - 03 May 2017
Cited by 30 | Viewed by 4497
Abstract
One new meroterpenoid, named 2-hydroacetoxydehydroaustin (1), together with nine known meroterpenoids, 11-acetoxyisoaustinone (2), isoaustinol (3), austin (4), austinol (5), acetoxydehydroaustin (6), dehydroaustin (7), dehydroaustinol (8), preaustinoid A2 [...] Read more.
One new meroterpenoid, named 2-hydroacetoxydehydroaustin (1), together with nine known meroterpenoids, 11-acetoxyisoaustinone (2), isoaustinol (3), austin (4), austinol (5), acetoxydehydroaustin (6), dehydroaustin (7), dehydroaustinol (8), preaustinoid A2 (9), and 1,2-dihydro-acetoxydehydroaustin B (10), were isolated from the mangrove endophytic fungus, Aspergillus sp. 16-5c. These structures were characterized by spectroscopic analysis, further the absolute configurations of stereogenic carbons for Compounds 1, 3, 4, 6, 7, 8, 9, and 10 were determined by single crystal X-ray diffraction analysis using Cu Kα radiation. Moreover, the absolute configurations of stereogenic carbons for Known Compounds 3, 7, 8, and 9 are identified here for the first time. Compounds 3, 7, and 8 showed acetylcholinesterase (AchE) inhibitory activity with IC50 values of 2.50, 0.40, and 3.00 μM, respectively. Full article
(This article belongs to the Special Issue Metabolites of Terrestrial and Marine Origin on the Age-Related Disorders)
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2134 KiB  
Article
2-Hydroxymelatonin, a Predominant Hydroxylated Melatonin Metabolite in Plants, Shows Antitumor Activity against Human Colorectal Cancer Cells
by Yi Yang, Rui Zhou, So-Yeon Park, Kyoungwhan Back, Woo Kyun Bae, Kyung Keun Kim and Hangun Kim
Molecules 2017, 22(3), 453; https://doi.org/10.3390/molecules22030453 - 14 Mar 2017
Cited by 17 | Viewed by 5148
Abstract
2-Hydroxymelatonin is a predominant hydroxylated melatonin metabolite in plants. To investigate whether it has potent cytotoxic effects on colorectal cancer cells, four colorectal cancer cell lines, Caco2, HCT116, DLD1, and CT26, were treated with 2-hydroxymelatonin and melatonin. 2-Hydroxymelatonin had a much lower IC [...] Read more.
2-Hydroxymelatonin is a predominant hydroxylated melatonin metabolite in plants. To investigate whether it has potent cytotoxic effects on colorectal cancer cells, four colorectal cancer cell lines, Caco2, HCT116, DLD1, and CT26, were treated with 2-hydroxymelatonin and melatonin. 2-Hydroxymelatonin had a much lower IC50 value than melatonin in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cytotoxic effect of 2-hydroxymelatonin was much stronger than that of melatonin at high concentrations (1000 or 2000 μM) in HCT116, DLD1, and CT26 cells, but only at intermediate concentrations (250 or 500 μM) in Caco2 cells. The cytotoxicity of 2-hydroxymelatonin was induced through activation of the apoptotic signaling pathway, as confirmed by Hoechst staining and Annexin V-FITC/propidium iodide double labeling of cells treated with a lethal dose (1 mM). However, sub-lethal doses of 2-hydroxymelatonin inhibited the invasive ability of Caco2 cells. Epithelial-mesenchymal transition (EMT) markers were significantly regulated by 2-hydroxymelatonin. Overall, the anti-cancer activity of 2-hydroxymelatonin is more potent than that of melatonin. Taken together, 2-hydroxymelatonin exhibits potent anti-cancer activity against human colorectal cancer cells via induction of apoptosis and inhibition of EMT. Full article
(This article belongs to the Special Issue Metabolites of Terrestrial and Marine Origin on the Age-Related Disorders)
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525 KiB  
Article
Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
by Li-Hong Huang, Yan-Xiu Chen, Jian-Chen Yu, Jie Yuan, Hou-Jin Li, Wen-Zhe Ma, Ramida Watanapokasin, Kun-Chao Hu, Shah Iram Niaz, De-Po Yang and Wen-Jian Lan
Molecules 2017, 22(3), 444; https://doi.org/10.3390/molecules22030444 - 11 Mar 2017
Cited by 10 | Viewed by 5157
Abstract
Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including [...] Read more.
Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC50 values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. Full article
(This article belongs to the Special Issue Metabolites of Terrestrial and Marine Origin on the Age-Related Disorders)
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Review

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2543 KiB  
Review
An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs
by Verónica Ruiz-Torres, Jose Antonio Encinar, María Herranz-López, Almudena Pérez-Sánchez, Vicente Galiano, Enrique Barrajón-Catalán and Vicente Micol
Molecules 2017, 22(7), 1037; https://doi.org/10.3390/molecules22071037 - 23 Jun 2017
Cited by 153 | Viewed by 13850
Abstract
Marine secondary metabolites are a promising source of unexploited drugs that have a wide structural diversity and have shown a variety of biological activities. These compounds are produced in response to the harsh and competitive conditions that occur in the marine environment. Invertebrates [...] Read more.
Marine secondary metabolites are a promising source of unexploited drugs that have a wide structural diversity and have shown a variety of biological activities. These compounds are produced in response to the harsh and competitive conditions that occur in the marine environment. Invertebrates are considered to be among the groups with the richest biodiversity. To date, a significant number of marine natural products (MNPs) have been established as antineoplastic drugs. This review gives an overview of MNPs, both in research or clinical stages, from diverse organisms that were reported as being active or potentially active in cancer treatment in the past seventeen years (from January 2000 until April 2017) and describes their putative mechanisms of action. The structural diversity of MNPs is also highlighted and compared with the small-molecule anticancer drugs in clinical use. In addition, this review examines the use of virtual screening for MNP-based drug discovery and reveals that classical approaches for the selection of drug candidates based on ADMET (absorption, distribution, metabolism, excretion, and toxicity) filtering may miss potential anticancer lead compounds. Finally, we introduce a novel and publically accessible chemical library of MNPs for virtual screening purposes. Full article
(This article belongs to the Special Issue Metabolites of Terrestrial and Marine Origin on the Age-Related Disorders)
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