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New Natural Products: Isolation, Structural Elucidation, and Bioactivities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5801

Special Issue Editor


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Guest Editor
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Interests: natural products; phytochemistry; phytochemical analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products have played a very important role in drug discovery, such as paclitaxel, camptothecin, and berbamine. Natural product investigations on various natural sources guide us to a better understanding of constituents, bioactivities, and structure–activity relationships. Most natural products are characterized by enormous scaffold diversity and structural complexity. Additionally, the structural elucidation of new compounds might involve the elucidation of conformation and configuration, which could be useful toward a comprehensive analysis of MS, NMR, X-ray diffraction, circular dichroism, and chemical calculations. Bioactive natural products are mostly specific metabolites of natural sources with anticancer, anti-inflammatory, antibacterial, antivirus, anti-oxidation properties, etc. They may also lead to modern discovery or the development of new drugs.

We invite researchers to contribute original and review articles presenting their work in isolation, as well as structural elucidation and pharmacological investigation of new natural constituents from plants, fungus, and other living organisms in nature. We welcome papers presenting the isolation and elucidation of new bioactive compounds, pharmacological effects and mechanisms, and the discussion of structure–activity relationships.

Prof. Dr. Qingwen Zhang
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new natural products
  • extraction
  • isolation and purification
  • bioactivity
  • pharmacological effect and mechanism
  • structure–activity relationship

Published Papers (2 papers)

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Research

14 pages, 11521 KiB  
Article
Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the Mushroom Neonothopanus nambi
by Awat Wisetsai, Ratsami Lekphrom, Sureeporn Bua-art, Thanapat Suebrasri, Sophon Boonlue, Sarawut Tontapha, Vittaya Amornkitbamrung, Thanaset Senawong and Florian T. Schevenels
Molecules 2021, 26(24), 7667; https://doi.org/10.3390/molecules26247667 - 17 Dec 2021
Cited by 9 | Viewed by 2882
Abstract
Seven undescribed scalarane sesterterpenoids, nambiscalaranes B–H (17), together with two known compounds, nambiscalarane (8) and aurisin A (9) were isolated from the cultured mycelium of the luminescent mushroom Neonothopanus nambi. Their structures were elucidated [...] Read more.
Seven undescribed scalarane sesterterpenoids, nambiscalaranes B–H (17), together with two known compounds, nambiscalarane (8) and aurisin A (9) were isolated from the cultured mycelium of the luminescent mushroom Neonothopanus nambi. Their structures were elucidated by thorough analysis of their 1D and 2D NMR spectroscopic data. The absolute configurations of 18 were determined by electronic circular dichroism (ECD) calculations and optical rotation measurements. The isolated sesterterpenoids were evaluated against A549, HT29, HeLa, and HCT-116 cancer cell lines, and against five bacterial strains. Compounds 3, 5, and 7 showed strong cytotoxicity against HCT-116 cell line, with IC50 values ranging from 13.41 to 16.53 µM, and showed no cytotoxicity towards Vero cells. Moreover, compound 8 inhibited the growth of Bacillus subtilis with a MIC value of 8 µg/mL, which was equivalent to the MIC value of the standard kanamycin. Full article
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9 pages, 1862 KiB  
Article
Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
by Sheng-Yuan Zhang, Zi-Wei Li, Jie Xu, Qiu-Ling Chen, Min Song and Qing-Wen Zhang
Molecules 2021, 26(23), 7191; https://doi.org/10.3390/molecules26237191 - 27 Nov 2021
Cited by 2 | Viewed by 1932
Abstract
Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods [...] Read more.
Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC50 value of 8.7 μM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory activities, with IC50 values of 26.8 and 29.2 μM, respectively. Full article
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