Oligosaccharide Synthesis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (31 October 2018) | Viewed by 4512
Special Issue Editor
Special Issue Information
Dear Colleagues,
Advances in glycobiology are made at an ever-increasing pace. This makes today an exciting time to carry out research in carbohydrate chemistry and biology. The rapid progress in the field is catalyzed by the development of new techniques—but also owes a lot to the many developments within the efficient, stereoselective total synthesis of oligosaccharides of high complexity. The advent of new methodologies for (chemoenzymatic) glycosylation, efficient strategies and recently also the use of supports that facilitate the automation of glycan assembly is rapidly pushing the field toward a new era of glycomics. Oligosaccharide synthesis remains a challenging area of research, where we are yet to see methodology of sufficient generality to be applicable to most, and certainly not all, targets. Nonetheless, the toolbox of conditions, glycosyl donors and strategies is increasing, and so is our understanding of the forces that govern reactivity and selectivity in glycosylation chemistry. The long-term goal for the field should be to enable routine access to all oligosaccharides required for biological research, as analytical standards, for development of drugs and vaccines, etc., even for non-experts. The present Special Issue aims at covering new synthetic methodologies in oligosaccharide synthesis, novel targets procured and additional understanding of reactivity in carbohydrate chemistry.
Prof. Dr. Mads Hartvig Clausen
Guest Editor
Manuscript Submission Information
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Keywords
- oligosaccharides
- carbohydrate chemistry
- synthetic methods
- natural products
- glycosylation
- glycobiology
