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Molecules
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Structure Elucidation and Development of Bioactive Compounds from Symbiotic Organisms
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Structure Elucidation and Development of Bioactive Compounds from Symbiotic Organisms

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (1 June 2022) | Viewed by 3960

Special Issue Editor

Dr. Harinantenaina Liva Rakotondraibe

E-Mail Website
Guest Editor
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
Interests: natural products; structure elucidation; anticancer; antimalarial; antibacterial; vector control; new natural product sources; endophytes; lichens and mycobionts; soil and marine microbes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products are a prominent source of bioactive compounds. During the last decade, a growing number of new and bioactive natural products have been discovered and identified from symbiotic microorganisms. Research has also shown that these unique and bioactive secondary metabolites have been produced not only to benefit the mutual relationship between the host and the symbiotic organism but also for their protection against predators. Digging these unique novel and bioactive compounds from symbiotic organisms is worthwhile, since they not only show influences on human life but can also be used as chemical probes in many pharmacological mechanistic studies.

This Special issue aims to publish research papers dealing with the discovery and structure elucidation (using spectroscopic techniques such as mass spectrometry, nuclear magnetic resonance, circular dichroism, etc.) of new and bioactive secondary metabolites from symbiotic organisms. These organisms include but are not limited to epiphytic and endophytic microbes of plants, marine organisms, and their microbial associates.

Dr. Harinantenaina Liva Rakotondraibe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • symbiotic
  • plants
  • microbes
  • marine organisms
  • secondary metabolites
  • bioactive compounds
  • structure elucidation
  • spectroscopic techniques

Published Papers (2 papers)

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Research

7 pages, 1405 KiB  
Article
Understanding the Biosynthesis of Paxisterol in Lichen-Derived Penicillium aurantiacobrunneum for Production of Fluorinated Derivatives
by Yoshi Yamano and Harinantenaina L. Rakotondraibe
Molecules 2022, 27(5), 1641; https://doi.org/10.3390/molecules27051641 - 02 Mar 2022
Viewed by 1781
Abstract
The U.S. endemic lichen (Niebla homalea)-derived Penicillium aurantiacobrunneum produced a cytotoxic paxisterol derivative named auransterol (2) and epi-citreoviridin (6). Feeding assay using 13C1-labelled sodium acetate not only produced C-13-labelled paxisterol but also confirmed [...] Read more.
The U.S. endemic lichen (Niebla homalea)-derived Penicillium aurantiacobrunneum produced a cytotoxic paxisterol derivative named auransterol (2) and epi-citreoviridin (6). Feeding assay using 13C1-labelled sodium acetate not only produced C-13-labelled paxisterol but also confirmed the biosynthetic origin of the compound. The fluorination of bioactive compounds is known to improve pharmacological and pharmacokinetic effects. Our attempt to incorporate the fluorine atom in paxisterol and its derivatives using the fluorinated precursor sodium monofluoroacetate resulted in the isolation of 7-monofluoroacetyl paxisterol (7). The performed culture experiment, as well as the isolation and structure elucidation of the new fluorinated paxisterol, is discussed herein. Full article
(This article belongs to the Special Issue Structure Elucidation and Development of Bioactive Compounds from Symbiotic Organisms)
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20 pages, 4675 KiB  
Article
Promoting Effect of Soluble Polysaccharides Extracted from Ulva spp. on Zea mays L. Growth
by Ragaa A. Hamouda, Mervat H. Hussein, Noura El-Ahmady El-Naggar, Mohammed A. Karim-Eldeen, Khalid H. Alamer, Muneera A. Saleh, Luluah M. Al Masoudi, Eman M. Sharaf and Reham M. Abd El-Azeem
Molecules 2022, 27(4), 1394; https://doi.org/10.3390/molecules27041394 - 18 Feb 2022
Cited by 10 | Viewed by 1802
Abstract
Seaweeds can play a vital role in plant growth promotion. Two concentrations (5 and 10 mg/mL) of soluble polysaccharides extracted from the green macroalgae Ulva fasciata and Ulva lactuca were tested on Zea mays L. The carbohydrate and protein contents, and antioxidant activities [...] Read more.
Seaweeds can play a vital role in plant growth promotion. Two concentrations (5 and 10 mg/mL) of soluble polysaccharides extracted from the green macroalgae Ulva fasciata and Ulva lactuca were tested on Zea mays L. The carbohydrate and protein contents, and antioxidant activities (phenols, ascorbic, peroxidase, and catalase) were measured, as well as the protein banding patterns. The soluble polysaccharides at 5 mg/mL had the greatest effect on the base of all of the parameters. The highest effects of soluble polysaccharides on the Zea mays were 38.453, 96.76, 4, 835, 1.658, 7.462, and 38615.19, mg/mL for carbohydrates, proteins, phenol, µg ascorbic/mL, mg peroxidase/g dry tissue, and units/g tissue of catalase, respectively. The total number of protein bands (as determined by SDS PAGE) was not changed, but the density of the bands was correlated to the treatments. The highest band density and promoting effect were correlated to 5 mg/mL soluble polysaccharide treatments extracted from Ulva fasciata in Zea mays, which can be used as a biofertilizer. Full article
(This article belongs to the Special Issue Structure Elucidation and Development of Bioactive Compounds from Symbiotic Organisms)
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