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Nanomaterials
Special Issues
Toxicity of Engineered Nanomaterials: Current Understanding and Challenges
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Toxicity of Engineered Nanomaterials: Current Understanding and Challenges

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Environmental Nanoscience and Nanotechnology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1177

Special Issue Editors

Dr. Man Qu

E-Mail Website
Guest Editor
School of Nursing & School of Public Health, Yangzhou University, Yangzhou 225000, China
Interests: nanotoxicology and nanosafety; environmental toxicology
Special Issues, Collections and Topics in MDPI journals
Dr. Luz Stella Gomez-Villalba

E-Mail Website
Guest Editor
Institute of Geosciences (Spanish Council of Research (CSIC), Complutense University of Madrid), Madrid, Spain
Interests: nano-scale phase transformation processes; multifunctional nanomaterials; alternative safe nano-synthesis methods; building materials; heritage conservation (photocatalytic, consolidant, hydrophobic, hydrophilic, flame retardant, or anti-fungal); petrology; mineralogy; crystallography; latest-generation characterization techniques; natural-origin nanomaterials and tracing methods; multifunctional nanomaterials; nano-risks; nano-safety; nano-prevention; alternative synthesis; handling; environmental risks; tracing methods; building materials; natural-origin nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of engineered nanomaterials (ENMs) in consumer and biomedical products is growing rapidly, leading to an increase in organismal exposure to these materials. As a result, it is crucial to understand their safety implications, which is of paramount importance to the public. In certain critical sectors such as construction materials, metallurgy, mining, and conservation and restoration, there is a significant risk associated with the emission of nanomaterials. Despite the use of various animal models and cell-line-based simulations to evaluate the toxicity and underlying mechanisms of nanomaterials, our understanding of nanotoxicity mechanisms remains limited. Therefore, there is a need to develop a more comprehensive understanding of this issue and identify potential solutions.

This Special Issue aims to consolidate our current knowledge and the challenges related to the toxicity of ENMs. By doing so, it has significant predictive potential in expanding our understanding of the potential biological effects, behavior, and underlying mechanisms of ENMs in mammals and humans.

This Special issue will welcome manuscripts on the following topics:

  • Safety evaluation and toxicological mechanisms of emerging nanomaterials;
  • Chemical modification-based screening of low-toxicity nanomaterials;
  • Adverse outcome pathways (AOPs) and predictive nanotoxicology;
  • Pharmacological strategies and toxicity prevention of nanomaterials;
  • Removal technology and mechanism of nanomaterials;
  • Ecotoxicological evaluation and toxicology models in model animals.

Dr. Man Qu
Dr. Luz Stella Gomez-Villalba
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging ENMs
  • environmental removal technology
  • nanotoxicology
  • AOPs
  • toxicity prevention
  • ecotoxicological evaluation

Published Papers (2 papers)

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Research

20 pages, 4848 KiB  
Article
Pyroclastic Dust from Arequipa-Peru Decorated with Iron Oxide Nanoparticles and Their Ecotoxicological Properties in Water Flea D. magna
by Juan A. Ramos-Guivar, Yacu V. Alca-Ramos, Erich V. Manrique-Castillo, F. Mendoza-Villa, Noemi-Raquel Checca-Huaman, Renzo Rueda-Vellasmin and Edson C. Passamani
Nanomaterials 2024, 14(9), 785; https://doi.org/10.3390/nano14090785 - 30 Apr 2024
Viewed by 434
Abstract
A novel magnetic composite made of Peruvian pyroclastic dust material decorated with maghemite nanoparticles was synthesized and characterized using a variety of analytic techniques. The 13 nm maghemite nanoparticles were grown on the pyroclastic dust using the conventional coprecipitation chemical route. A short-term [...] Read more.
A novel magnetic composite made of Peruvian pyroclastic dust material decorated with maghemite nanoparticles was synthesized and characterized using a variety of analytic techniques. The 13 nm maghemite nanoparticles were grown on the pyroclastic dust using the conventional coprecipitation chemical route. A short-term acute assay was developed to study the ecotoxicological behavior of the water flea, Daphnia magna. A 24 h-lethal concentration (LC50) value equal to 123.6 mg L−1 was determined only for the magnetic composite. While the pyroclastic dust material did not exhibit a lethal concentration, it caused morphologically significant changes (p < 0.05) for heart and tail parameters at high concentrations. Morphologies exposed to the magnetic composite above the 24 h-LC50 revealed less tolerance and significant changes in the body, heart, antenna, and eye. Hence, it affects biomarker growth and swimming. The reproduction rate was not affected by the raw pyroclastic dust material. However, the number of individuals showed a decrease with increasing composite concentrations. The present study indicates the LC50 value, which can be used as a reference concentration for in-situ water cleaning with this material without damaging or changing the Daphnia magna ecosystem. Full article
(This article belongs to the Special Issue Toxicity of Engineered Nanomaterials: Current Understanding and Challenges)
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16 pages, 5266 KiB  
Article
Mitochondrial Fission in Nickel Nanoparticle-Induced Reproductive Toxicity: An In Vitro GC-1 Cell Study
by Hanyue Zheng, Geyu Liang, Chunliu Guan, Lin Liu, Jiahui Dong, Jinshun Zhao, Meng Tang and Lu Kong
Nanomaterials 2024, 14(8), 689; https://doi.org/10.3390/nano14080689 - 17 Apr 2024
Viewed by 461
Abstract
Reproductive disorders and declining fertility rates are significant public health concerns affecting birth rates and future populations. Male infertility, often due to spermatogenesis defects, may be linked to environmental pollutants like nickel nanoparticles (Ni NPs). Ni NPs are extensively utilized across different industries. [...] Read more.
Reproductive disorders and declining fertility rates are significant public health concerns affecting birth rates and future populations. Male infertility, often due to spermatogenesis defects, may be linked to environmental pollutants like nickel nanoparticles (Ni NPs). Ni NPs are extensively utilized across different industries. Nevertheless, their potential adverse effects cannot be overlooked. Previous studies have linked the reproductive toxicity induced by Ni NPs with disturbances in mitochondrial function. Mitochondrial division/fusion dynamics are crucial to their proper function, yet little is known about how Ni NPs perturb these dynamics and whether such perturbation contributes to the impairment of the male reproductive system. Herein, we demonstrated that the exposure of Ni NPs to the mouse-derived spermatogonia cell line (GC-1 cells) triggered DRP1-mediated mitochondrial division and the enhanced impairment of mitochondria, consequently promoting mitochondria-dependent cell apoptosis. Notably, both the mitochondrial division inhibitor (Mdivi-1) and lentiviral-transfected cells with low expression of Dnm1l-DK in these cells could mitigate the toxic effects induced by Ni NPs, pointing to the potential role of mitochondrial dynamics in Ni NP-induced reproductive toxicity. Collectively, our work contributes to the understanding of the mechanisms by which Ni NPs can impact male reproductive function and identifies mitochondrial division as a potential target for intervention. Full article
(This article belongs to the Special Issue Toxicity of Engineered Nanomaterials: Current Understanding and Challenges)
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